Evidence map›Paper›PMID 22427326›Full record

ReviewCirculation research2012

Lymphocytes and the adventitial immune response in atherosclerosis.

Kirsti A Campbell, Michael J Lipinski, Amanda C Doran, Marcus D Skaflen, Valentin Fuster, Coleen A McNamara

Registry-linked trialAbstract readReview
In one paragraph

Review in Circulation research, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02428374 (Role of Innate and Adaptive Immunity After Acute Myocardial Infarction BATTLE-AMI Study), which is not on this map. Cited by 67 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
67citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02428374 phase4unknown statusstarted 2015, after this paper: background citation

Role of Innate and Adaptive Immunity After Acute Myocardial Infarction BATTLE-AMI Study (B And T Types of Lymphocytes Evaluation in Acute Myocardial Infarction)

Ran2015Enrolled300Registered outcomes30Posted comparisons0ConditionsMyocardial FibrosisArmsRosuvastatin plus clopidogrel, Rosuvastatin plus ticagrelor, Simvastatin plus clopidogrel, Simvastatin plus ticagrelor
Open the trial in the graph
3 · Its place in the literature

Who cites it

67 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Trial
  3. B lymphocytes and hyperglycemia synergistically exacerbate coronary in-stent restenosis.International journal of cardiology. Cardiovascular risk and prevention · 2026
    Article
  4. Review
  5. Review
  6. Article
  7. Review
  8. Article
  9. Article
  10. Review
  11. Article
  12. Article
  13. Application of Photodynamic Therapy in Cardiology.International journal of molecular sciences · 2024
    Review
  14. Effects of gold nanoparticles phytoreduced withMedicine and pharmacy reports · 2024
    Article
  15. Perivascular Adipose Tissue Oxidative Stress in Obesity.Antioxidants (Basel, Switzerland) · 2023
    Review
  16. Review
  17. Article
  18. Article
  19. Review
  20. Review

7 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Kirsti A CampbellCardiovascular Research Center, University of Virginia, Charlottesville, USA.
Michael J Lipinski
Amanda C Doran
Marcus D Skaflen
Valentin Fuster
Coleen A McNamara

Funding

ROLE OF LIPOXYGENASES IN ATHEROGENESIS IN DIABETES MELLITUSP01HL055798 · NHLBI · UNIVERSITY OF VIRGINIA CHARLOTTESVILLE · PI HEDRICK, CATHERINE C · 1995 to 2016
$28.4M
MEDICAL SCIENTIST TRAINING PROGRAMT32GM007267 · NIGMS · UNIVERSITY OF VIRGINIA CHARLOTTESVILLE · PI GARCIA-BLANCO, MARIANO A. · 1985 to 2024
$13.4M
Local B-1 Regulation of AtherosclerosisR01HL136098 · NHLBI · UNIVERSITY OF VIRGINIA · PI MCNAMARA, COLEEN A · 2017 to 2020
$3.1M
Vascular Biology ResearchT32HL007355 · NHLBI · UNIVERSITY OF VIRGINIA CHARLOTTESVILLE · PI MCNAMARA, COLEEN A · 1985 to 2009
$2.6M
Genetic Regulation of B Lymphocyte Aortic Homing and AtheroprotectionR01HL107490 · NHLBI · UNIVERSITY OF VIRGINIA · PI MCNAMARA, COLEEN A · 2011 to 2014
$1.5M
Id3/B Lymphocytes and AtherosclerosisR01HL096447 · NHLBI · UNIVERSITY OF VIRGINIA · PI MCNAMARA, COLEEN A · 2009 to 2010
$1.0M
NHLBI NIH HHS P01 HL055798NHLBI NIH HHS P01 HL55798NHLBI NIH HHS R01 HL096447NHLBI NIH HHS R01 HL107490NHLBI NIH HHS R01 HL136098NHLBI NIH HHS T32 HL007355NHLBI NIH HHS T32 HL007355-29
6 · The paper itself

Abstract

Although much of the research on atherosclerosis has focused on the intimal accumulation of lipids and inflammatory cells, there is an increasing amount of interest in the role of the adventitia in coordinating the immune response in atherosclerosis. In this review of the contributions of the adventitia and adventitial lymphocytes to the development of atherosclerosis, we discuss recent research on the formation and structural nature of adventitial immune aggregates, potential mechanisms of crosstalk between the intima, media, and adventitia, specific contributions of B lymphocytes and T lymphocytes, and the role of the vasa vasorum and surrounding perivascular adipose tissue. Furthermore, we highlight techniques for the imaging of lymphocytes in the vasculature.

Indexed as

AnimalsAtherosclerosisConnective TissueHumansLymphocytes

Identifiers

PMID22427326
PMCPMC3373006

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.