SynthesisInflammation research : official journal of the European Histamine Research Society ... [et al.]2012
The association between interleukin-6 polymorphisms and rheumatoid arthritis: a meta-analysis.
Synthesis in Inflammation research : official journal of the European Histamine Research Society ... [et al.], 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 3 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- Association of interleukin-6 promoter polymorphism with rheumatoid arthritis: a meta-analysis with trial sequential analysis.Clinical rheumatology · 2022Pooled it
- Functional FCGR3A 158 V/F and IL-6 -174 C/G polymorphisms predict response to biologic therapy in patients with rheumatoid arthritis: a meta-analysis.Rheumatology international · 2014Pooled it
- Association between interleukin-6 gene polymorphisms and rheumatoid arthritis in Chinese Han population: a case-control study and a meta-analysis.Scientific reports · 2014Pooled it
- Impact of IL6 and IL18 Promoter Polymorphisms on Circulating Cytokine Levels, Gene Expression, and Susceptibility to Rheumatoid Arthritis.International journal of molecular sciences · 2026Article
- The interleukin-1 beta 511C>T polymorphism is associated with susceptibility to juvenile idiopathic arthritis in a Turkish population.Revista da Associacao Medica Brasileira (1992) · 2026Article
- Frequency Evaluation of theInternational journal of molecular sciences · 2023Article
- Clinical Management of Il-6 Driven Cytokine Storm Related to COVID-19 in a Patient with Recent Spinal Cord Stimulator Implants: A Case Report.Anesthesiology and pain medicine · 2020Article
- Flavonoid quercetin-methotrexate combination inhibits inflammatory mediators and matrix metalloproteinase expression, providing protection to joints in collagen-induced arthritis.Inflammopharmacology · 2018Article
- Article
- Association of interleukin-6 single nucleotide polymorphisms with juvenile idiopathic arthritis.Clinical rheumatology · 2017Article
- Genetic and environmental determinants of population variation in interleukin-6, its soluble receptor and C-reactive protein: insights from identical and fraternal twins.Brain, behavior, and immunity · 2015Article
- Interleukins and interleukin receptors in rheumatoid arthritis: Research, diagnostics and clinical implications.World journal of orthopedics · 2014Review
- IL-6 in inflammation, immunity, and disease.Cold Spring Harbor perspectives in biology · 2014Review
- The effects of gene polymorphisms in interleukin-4 and interleukin-6 on the susceptibility of rheumatoid arthritis in a Chinese population.BioMed research international · 2014Article
- TGF-β1 limits the onset of innate lung inflammation by promoting mast cell-derived IL-6.Journal of immunology (Baltimore, Md. : 1950) · 2013Article
- RAvariome: a genetic risk variants database for rheumatoid arthritis based on assessment of reproducibility between or within human populations.Database : the journal of biological databases and curation · 2013Article
- A posteriori evaluation of effects attributed to IL-6 gene regulatory variants.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2012Article
- Potential of ayurgenomics approach in complex trait research: leads from a pilot study on rheumatoid arthritis.PloS one · 2012Article
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveThe aim of this study was to determine whether the functional interleukin-6 (IL-6) promoter -174 G/C and -572 G/C polymorphisms confer susceptibility to rheumatoid arthritis (RA) in ethnically different populations.
methodsMeta-analysis was conducted on the associations between these IL-6 polymorphisms and RA.
resultsA total of nine studies involving 3,851 subjects (RA 2,053 and controls 1,798) were considered in this study and ethnicity-specific meta-analysis was performed on European subjects. In all study subjects, meta-analysis revealed a trend toward to an association between RA and the IL-6 -174 G allele (odds ratio [OR] = 0.699, 95 % confidence interval [CI] = 0.463-1.054, p = 0.088). Stratification by ethnicity indicated a significant association between RA and the IL-6 -174 G/C polymorphism in Europeans using the dominant (OR = 0.329, 95 % CI = 0.155-0.699, p = 0.004) and recessive (OR = 0.823, 95 % CI = 0.679-0.997, p = 0.047) models. Meta-analysis of the IL-6 -572 G/C polymorphism showed no association between RA and the IL-6 -572 G allele in all study subjects (OR = 1.641, 95 % CI = 0.613-4.397, p = 0.324).
conclusionsThis meta-analysis shows that the IL-6 -174 G/C polymorphism may confer susceptibility to RA in Europeans.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.