ArticleJournal of the American Society for Mass Spectrometry2012
Reactions of microsolvated organic compounds at ambient surfaces: droplet velocity, charge state, and solvent effects.
Article in Journal of the American Society for Mass Spectrometry, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
20 citing papers in PubMed, 81 citations in OpenAlex.
- Article
- Mechanisms of ionization and of chemical reactions in charged microdroplets.Chemical science · 2025Review
- Sulfuric Acid Catalyzed Esterification of Amino Acids in Thin Film.Journal of the American Society for Mass Spectrometry · 2023Article
- In-droplet hydrogen-deuterium exchange to examine protein/peptide solution conformer heterogeneity.Rapid communications in mass spectrometry : RCM · 2023Article
- Article
- Accelerated nucleophilic substitution reactions of dansyl chloride with aniline under ambient conditions via dual-tip reactive paper spray.Scientific reports · 2020Article
- Molecular reactions at aqueous interfaces.Nature reviews. Chemistry · 2020Review
- Accelerated microdroplet synthesis of benzimidazoles by nucleophilic addition to protonated carboxylic acids.Chemical science · 2020Article
- Localization of sterols and oxysterols in mouse brain reveals distinct spatial cholesterol metabolism.Proceedings of the National Academy of Sciences of the United States of America · 2020Article
- A microdroplet-accelerated Biginelli reaction: mechanisms and separation of isomers using IMS-MS.Chemical science · 2019Article
- Toward Mass Spectrometry Imaging in the Metabolomics Scale: Increasing Metabolic Coverage Through Multiple On-Tissue Chemical Modifications.Frontiers in plant science · 2019Article
- Going beyond electrospray: mass spectrometric studies of chemical reactions in and on liquids.Chemical science · 2016Article
- Multistage Reactive Transmission-Mode Desorption Electrospray Ionization Mass Spectrometry.Journal of the American Society for Mass Spectrometry · 2015Article
- Theta-glass capillaries in electrospray ionization: rapid mixing and short droplet lifetimes.Analytical chemistry · 2014Article
- In situ SIMS and IR spectroscopy of well-defined surfaces prepared by soft landing of mass-selected ions.Journal of visualized experiments : JoVE · 2014Article
- Recent advances in experimental techniques to probe fast excited-state dynamics in biological molecules in the gas phase: dynamics in nucleotides, amino acids and beyond.Proceedings. Mathematical, physical, and engineering sciences · 2013Review
- Probing the reactivity and radical nature of oxidized transition metal-thiolate complexes by mass spectrometry.Journal of the American Society for Mass Spectrometry · 2013Article
- Accelerated C-N bond formation in dropcast thin films on ambient surfaces.Journal of the American Society for Mass Spectrometry · 2012Article
- Degradation strategies for structural characterization of insoluble synthetic polymers by mass spectrometry.Mass spectrometry reviewsReview
- A Comprehensive Review of Instrumentation and Applications in Post-Column and In-Source Derivatization for LC-MS.Mass spectrometry reviewsReview
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The exposure of charged microdroplets containing organic ions to solid-phase reagents at ambient surfaces results in heterogeneous ion/surface reactions. The electrosprayed droplets were driven pneumatically in ambient air and then electrically directed onto a surface coated with reagent. Using this reactive soft landing approach, acid-catalyzed Girard condensation was achieved at an ambient surface by directing droplets containing Girard T ions onto a dry keto-steroid. The charged droplet/surface reaction was much more efficient than the corresponding bulk solution-phase reaction performed on the same scale. The increase in product yield is ascribed to solvent evaporation, which causes moderate pH values in the starting droplet to reach extreme values and increases reagent concentrations. Comparisons are made with an experiment in which the droplets were pneumatically accelerated onto the ambient surface (reactive desorption electrospray ionization, DESI). The same reaction products were observed but differences in spatial distribution were seen associated with the "splash" of the high velocity DESI droplets. In a third type of experiment, the reactions of charged droplets with vapor phase reagents were examined by allowing electrosprayed droplets containing a reagent to intercept the headspace vapor of an analyte. Deposition onto a collector surface and mass analysis showed that samples in the vapor phase were captured by the electrospray droplets, and that instantaneous derivatization of the captured sample is possible in the open air. The systems examined under this condition included the derivatization of cortisone vapor with Girard T and that of 4-phenylpyridine N-oxide and 2-phenylacetophenone vapors with ethanolamine.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.