ReviewNeurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics2012
Animal models of neurologic disorders: a nonhuman primate model of spinal cord injury.
Review in Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 48 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
48 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- Tracing the evolving dynamics and research hotspots of spinal cord injury and surgical decompression from 1975 to 2024: a bibliometric analysis.Frontiers in neurology · 2024Pooled it
- Systematic Evaluation of Spinal Cord Injury Animal Models in the Field of Biomaterials.Tissue engineering. Part B, Reviews · 2022Pooled it
- Fighting for recovery on multiple fronts: The past, present, and future of clinical trials for spinal cord injury.Frontiers in cellular neuroscience · 2022Pooled it
- Extensive restoration of forelimb function in primates with spinal cord injury by neural stem cell transplantation.Nature biotechnology · 2026Article
- The Fidelity Paradox in Spinal Cord Injury: Reframing Biomechanical Mimicry and Neurobiological Relevance for Clinical Translation.CNS neuroscience & therapeutics · 2026Review
- Immediate Consequences of a Spinal Cord Injury During Development: Unique Insights From Ex Vivo Models.Neural plasticity · 2026Review
- Animal Models of Spinal Cord Injury.Biomedicines · 2025Review
- Spinal cord injury models: Advantages and disadvantages in the view of pathophysiology and clinical significance.Biochemistry and biophysics reports · 2025Review
- Demonstration of therapeutic effect of plasma-synthesized polypyrrole/iodine biopolymer in rhesus monkey with complete spinal cord section.Journal of materials science. Materials in medicine · 2025Article
- Neurorehabilitation and white matter repair in traumatic spinal cord injury: a dialogue between clinical and preclinical studies.Frontiers in neurology · 2025Review
- Brachial Plexus Anatomy of Sprague Dawley Rat Compared to Human.Journal of brachial plexus and peripheral nerve injury · 2025Article
- Article
- Longitudinal multiparametric MRI of traumatic spinal cord injury in animal models.Magnetic resonance imaging · 2023Review
- Thermosensitive hydrogel-based GPR124 delivery strategy for rebuilding blood-spinal cord barrier.Bioengineering & translational medicine · 2023Article
- Single-cell analysis reveals region-heterogeneous responses in rhesus monkey spinal cord with complete injury.Nature communications · 2023Article
- Emergence of functionally aberrant and subsequent reduction of neuromuscular connectivity and improved motor performance after cervical spinal cord injury in Rhesus.Frontiers in rehabilitation sciences · 2023Article
- Locomotor Behavior Analysis in Spinal Cord InjuredVeterinary sciences · 2021Article
- How to generate graded spinal cord injuries in swine - tools and procedures.Disease models & mechanisms · 2021Article
- Longitudinal fMRI measures of cortical reactivation and hand use with and without training after sensory loss in primates.NeuroImage · 2021Article
- Unilateral cervical spinal cord injury induces bone loss and metabolic changes in non-human primates (Journal of orthopaedic translation · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
15 authors.
Funding
Abstract
Primates are an important and unique animal resource. We have developed a nonhuman primate model of spinal cord injury (SCI) to expand our knowledge of normal primate motor function, to assess the impact of disease and injury on sensory and motor function, and to test candidate therapies before they are applied to human patients. The lesion model consists of a lateral spinal cord hemisection at the C7 spinal level with subsequent examination of behavioral, electrophysiological, and anatomical outcomes. Results to date have revealed significant neuroanatomical and functional differences between rodents and primates that impact the development of candidate therapies. Moreover, these findings suggest the importance of testing some therapeutic approaches in nonhuman primates prior to the use of invasive approaches in human clinical trials. Our primate model is intended to: 1) lend greater positive predictive value to human translatable therapies, 2) develop appropriate methods for human translation, 3) lead to basic discoveries that might not be identified in rodent models and are relevant to human translation, and 4) identify new avenues of basic research to "reverse-translate" important questions back to rodent models.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.