ArticleAnalytical and bioanalytical chemistry2012
Electron spray ionization mass spectrometry and 2D 31P NMR for monitoring 18O/16O isotope exchange and turnover rates of metabolic oligophosphates.
Article in Analytical and bioanalytical chemistry, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed.
- Molecularly imprinted polyvinylbenzoic acid based sensor for highly sensitive detection of acute lymphoblastic leukemia biomarker.Analytical and bioanalytical chemistry · 2026Article
- Pools of Independently Cycling Inositol Phosphates Revealed by Pulse Labeling withJournal of the American Chemical Society · 2025Article
- Challenges in Identifying the Dark Molecules of Life.Annual review of analytical chemistry (Palo Alto, Calif.) · 2019Review
- Nutrition and metabolic correlates of obesity and inflammation: clinical considerations.The Journal of nutrition · 2015Review
- Decline of Phosphotransfer and Substrate Supply Metabolic Circuits Hinders ATP Cycling in Aging Myocardium.PloS one · 2015Article
- Stable isotope labeling of phosphoproteins for large-scale phosphorylation rate determination.Molecular & cellular proteomics : MCP · 2014Article
- 18O-assisted dynamic metabolomics for individualized diagnostics and treatment of human diseases.Croatian medical journal · 2012Review
- Preclinical (1)H-MRS neurochemical profiling in neurological and psychiatric disorders.Bioanalysis · 2012Review
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Authors and funding
9 authors.
Funding
Abstract
A new method was here developed for the determination of (18)O-labeling ratios in metabolic oligophosphates, such as ATP, at different phosphoryl moieties (α-, β-, and γ-ATP) using sensitive and rapid electrospray ionization mass spectrometry (ESI-MS). The ESI-MS-based method for monitoring of (18)O/(16)O exchange was validated with gas chromatography-mass spectrometry and 2D (31)P NMR correlation spectroscopy, the current standard methods in labeling studies. Significant correlation was found between isotopomer selective 2D (31)P NMR spectroscopy and isotopomer less selective ESI-MS method. Results demonstrate that ESI-MS provides a robust analytical platform for simultaneous determination of levels, (18)O-labeling kinetics and turnover rates of α-, β-, and γ-phosphoryls in ATP molecule. Such method is advantageous for large scale dynamic phosphometabolomic profiling of metabolic networks and acquiring information on the status of probed cellular energetic system.
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