ReviewProtein & cell2012
Sensing bacterial infections by NAIP receptors in NLRC4 inflammasome activation.
Review in Protein & cell, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
18 citing papers in PubMed.
- Non-coding RNAs as a Critical Player in the Regulation of Inflammasome in Inflammatory Bowel Diseases; Emphasize on lncRNAs.Cell biochemistry and biophysics · 2025Review
- Biomaterials Functionalized with Inflammasome Inhibitors-Premises and Perspectives.Journal of functional biomaterials · 2024Review
- Vitamin D receptor enhances NLRC4 inflammasome activation by promoting NAIPs-NLRC4 association.EMBO reports · 2022Article
- Inflammasome Regulation: Therapeutic Potential for Inflammatory Bowel Disease.Molecules (Basel, Switzerland) · 2021Review
- Gasdermin E-mediated programmed cell death: An unpaved path to tumor suppression.Journal of Cancer · 2021Review
- FliC's Hypervariable D3 Domain Is Required for Robust Anti-Flagellin Primary Antibody Responses.ImmunoHorizons · 2019Article
- Comparative analysis of expression of microbial sensing molecules in mucosal tissues with periodontal disease.Immunobiology · 2019Article
- Comparative analysis of microbial sensing molecules in mucosal tissues with aging.Immunobiology · 2018Article
- COPs and POPs Patrol Inflammasome Activation.Journal of molecular biology · 2018Review
- DNA sensor cGAS-mediated immune recognition.Protein & cell · 2016Review
- Article
- Evasion of inflammasome activation by microbial pathogens.The Journal of clinical investigation · 2015Review
- Inflammasomes are important mediators of cyclophosphamide-induced bladder inflammation.American journal of physiology. Renal physiology · 2014Article
- Article
- The NLRP3 inflammasome activation in human or mouse cells, sensitivity causes puzzle.Protein & cell · 2013Article
- Of inflammasomes and pathogens--sensing of microbes by the inflammasome.EMBO molecular medicine · 2013Review
- Negative regulation of NLRP3 inflammasome signaling.Protein & cell · 2013Review
- Expression regulation and function of NLRC5.Protein & cell · 2013Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
Abstract
The inflammasome is an emerging new pathway in innate immune defense against microbial infection or endogenous danger signals. The inflammasome stimulates activation of inflammatory caspases, mainly caspase-1. Caspase-1 activation is responsible for processing and secretion of IL-1β and IL-18 as well as for inducing macrophage pyroptotic death. Assembly of the large cytoplasmic inflammasome complex is thought to be mediated by members of NOD-like receptor (NLR) family. While functions of most of the NLR proteins remain to be defined, several NLR proteins including NLRC4 have been shown to assemble distinct inflammasome complexes. These inflammasome pathways, particularly the NLRC4 inflammasome, play a critical role in sensing and restricting diverse types of bacterial infections. Here we review recent advances in defining the exact bacterial ligands and the ligand-binding receptors involved in NLRC4 inflammasome activation. Implications of the discovery of the NAIP family of inflammasome receptors for bacterial flagellin and type III secretion apparatus on future inflammasome and bacterial infection studies are also discussed.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.