ReviewEndocrine2012
Pituitary autoimmune disease: nuances in clinical presentation.
Review in Endocrine, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
22 citing papers in PubMed, 51 citations in OpenAlex.
- Aberrant CD8Frontiers in immunology · 2024Article
- Hypophysitis: Defining Histopathologic Variants and a Review of Emerging Clinical Causative Entities.International journal of molecular sciences · 2023Review
- Typing of inflammatory lesions of the pituitary.Pituitary · 2022Article
- Full recovery from chronic headache and hypopituitarism caused by lymphocytic hypophysitis: A case report.World journal of clinical cases · 2022Article
- Imaging of Adverse Events Related to Checkpoint Inhibitor Therapy.Diagnostics (Basel, Switzerland) · 2020Review
- Neuro-radiological features can predict hypopituitarism in primary autoimmune hypophysitis.Pituitary · 2018Article
- Isolated Adrenocorticotropin Deficiency due to Nivolumab-induced Hypophysitis in a Patient with Advanced Lung Adenocarcinoma: A Case Report and Literature Review.Internal medicine (Tokyo, Japan) · 2018Review
- IgG4-related Hypophysitis with Subtle Hypopituitarism in an Elderly Diabetic Patient: Is Treatment or Observation Preferable?Internal medicine (Tokyo, Japan) · 2017Article
- Isolated Adrenocorticotropic Hormone Deficiency Caused by Nivolumab in a Patient with Metastatic Lung Cancer.Internal medicine (Tokyo, Japan) · 2017Article
- Cancer immunotherapy - immune checkpoint blockade and associated endocrinopathies.Nature reviews. Endocrinology · 2017Review
- Xanthomatous Hypophysitis Is Associated with Ruptured Rathke's Cleft Cyst.Endocrine pathology · 2017Article
- Autoimmune Hypophysitis Presenting as Solid-Cystic Mass Managed Conservatively.Polish journal of radiology · 2017Article
- CD1a Reactivity in Non-neoplastic Adenohypophysis.The American journal of surgical pathology · 2016Article
- Imaging Features of Toxicities by Immune Checkpoint Inhibitors in Cancer Therapy.Current radiology reports · 2016Review
- Lymphocytic infundibulo-neurohypophysitis: a clinical overview.Endocrine · 2015Review
- Ipilimumab-induced hypophysitis: review of the literature.Journal of endocrinological investigation · 2015Review
- Pituitary injury and persistent hypofunction resulting from a peripartum non-hemorrhagic, vaso-occlusive event.Endocrinology, diabetes & metabolism case reports · 2015Article
- A case of hypothalamic hypopituitarism accompanied by recurrent severe hypoglycemia.SpringerPlus · 2015Article
- Surgical biopsies in patients with central diabetes insipidus and thickened pituitary stalks.Endocrine · 2014Article
- Endocrine autoimmune diseases and female infertility.Nature reviews. Endocrinology · 2014Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Pituitary autoimmune disease is considered an autoimmune organ-specific disorder, characterized by a pituitary infiltration of lymphocytes, macrophages, and plasma cells that could lead to loss of pituitary function. Hypophysitis may be secondary to systemic diseases or infections. Primary pituitary hypophysitis is classified into lymphocytic, granulomatous, xanthomatous, mixed forms (lymphogranulomatous, xanthogranulomatous), necrotizing and IgG4 plasmacytic, according to the histological findings. Concerning lymphocytic hypophysitis (LH), it is characterized by lymphocytic infiltration and can be subclassified according to the affected area on: lymphocytic adenohypophysitis, lymphocytic infundibulo-neurohypophysitis and lymphocytic panhypophysitis. LH had always been considered a rare disease. Nevertheless, with improved imaging techniques, especially magnetic resonance imaging (MRI), LH diagnosis has been increased. This disease usually affects young women during pregnancy or postpartum period with headache, visual impairment, ACTH deficiency and a homogenous sellar mass with thickening of pituitary stalk in MRI. Definitive diagnosis depends on histopathological evaluation; nevertheless, a presumptive diagnosis could be done in a typical case. As no specific autoantigen was identified in LH, there is no antipituitary antibody (APA) method available for helping diagnosis. However, APA used in some centers for research could support an autoimmune origin for some hypopituitarism previously named as idiopathic, confirming nuances in clinical presentation of pituitary autoimmune disease. Therapeutic approach should be based on the grade of suspicious and clinical manifestations of LH.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.