ArticleFunctional & integrative genomics2012
Identification of mitochondrial thiamin diphosphate carriers from Arabidopsis and maize.
Article in Functional & integrative genomics, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 40 citations in OpenAlex.
- Optimizing thiamine pyrophosphate metabolism enhances crop yield and quality.Nature communications · 2025Article
- OsTH1 is a key player in thiamin biosynthesis in rice.Scientific reports · 2024Article
- OPA1 drives macrophage metabolism and functional commitment via p65 signaling.Cell death and differentiation · 2023Article
- Tumor growth of neurofibromin-deficient cells is driven by decreased respiration and hampered by NADCell death and differentiation · 2022Article
- B vitamin supply in plants and humans: the importance of vitamer homeostasis.The Plant journal : for cell and molecular biology · 2022Review
- Mitochondrial transport and metabolism of the vitamin B-derived cofactors thiamine pyrophosphate, coenzyme A, FAD and NADIUBMB life · 2022Review
- Metabolic engineering provides insight into the regulation of thiamin biosynthesis in plants.Plant physiology · 2021Article
- Metabolic engineering of rice endosperm towards higher vitamin B1 accumulation.Plant biotechnology journal · 2021Article
- Glufosinate constrains synchronous and metachronous metastasis by promoting anti-tumor macrophages.EMBO molecular medicine · 2020Article
- The importance of thiamine (vitamin BThe Journal of biological chemistry · 2020Review
- The coenzyme thiamine diphosphate displays a daily rhythm in the Arabidopsis nucleus.Communications biology · 2020Article
- Genome-Wide Identification and Expression Analysis of the UGlcAE Gene Family in Tomato.International journal of molecular sciences · 2018Article
- Toward Eradication of B-Vitamin Deficiencies: Considerations for Crop Biofortification.Frontiers in plant science · 2018Review
- Ancient Plant Glyoxylate/Succinic Semialdehyde Reductases: GLYR1s Are Cytosolic, Whereas GLYR2s Are Localized to Both Mitochondria and Plastids.Frontiers in plant science · 2017Article
- The Thiamine Biosynthesis Gene THI1 Promotes Nodule Growth and Seed Maturation.Plant physiology · 2016Article
- Long-Distance Transport of Thiamine (Vitamin B1) Is Concomitant with That of Polyamines.Plant physiology · 2016Article
- Genome-wide identification and characterization of Fox genes in the silkworm, Bombyx mori.Functional & integrative genomics · 2015Review
- Arabidopsis and maize RidA proteins preempt reactive enamine/imine damage to branched-chain amino acid biosynthesis in plastids.The Plant cell · 2014Article
- A unique N-terminal sequence in the Carnation Italian ringspot virus p36 replicase-associated protein interacts with the host cell ESCRT-I component Vps23.Journal of virology · 2014Article
- Transport pathways--proton motive force interrelationship in durum wheat mitochondria.International journal of molecular sciences · 2014Review
Corrections and comments
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Authors and funding
9 authors at 3 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
It is currently held that thiamin is made in chloroplasts and converted in the cytosol to the active cofactor thiamin diphosphate (ThDP), and that mitochondria and plastids import ThDP. The organellar transporters that mediate ThDP import in plants have not been identified. Comparative genomic analysis indicated that two members of the mitochondrial carrier family (MCF) in Arabidopsis (At5g48970 and At3g21390) and two in maize (GRMZM2G118515 and GRMZM2G124911) are related to the ThDP carriers of animals and Saccharomyces cerevisiae. Expression of each of these plant proteins in a S. cerevisiae ThDP carrier (TPC1) null mutant complemented the growth defect on fermentable carbon sources and restored the level of mitochondrial ThDP and the activity of the mitochondrial ThDP-dependent enzyme acetolactate synthase. The plant proteins were targeted to mitochondria as judged by dual import assays with purified pea mitochondria and chloroplasts, and by microscopic analysis of the subcellular localization of green fluorescent protein fusions in transiently transformed tobacco suspension cells. Both maize genes were shown to be expressed throughout the plant, which is consistent with the known ubiquity of mitochondrial ThDP-dependent enzymes. Collectively, these data establish that plants have mitochondrially located MCF carriers for ThDP, and indicate that these carriers are highly evolutionarily conserved. Our data provide a firm basis to propagate the functional annotation of mitochondrial ThDP carriers to other angiosperm genomes.
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