ReviewJournal of neural transmission (Vienna, Austria : 1996)2012
Where does a migraine attack originate? In the brainstem.
Review in Journal of neural transmission (Vienna, Austria : 1996), 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
9 citing papers in PubMed, 1 synthesis or guideline pooled it, 27 citations in OpenAlex.
- Systematic review of the pharmacological agents that have been tested against spreading depolarizations.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2018Pooled it
- Chronic Migraine as a Primary Chronic Pain Syndrome and Recommended Prophylactic Therapeutic Options: A Literature Review.Life (Basel, Switzerland) · 2023Review
- Changes in Brainstem Pain Modulation Circuitry Function over the Migraine Cycle.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2018Article
- Dynamic sodium imaging at ultra-high field reveals progression in a preclinical migraine model.Pain · 2018Article
- When light hurts: Comparative Morphometry of Human Brainstem in Traumatic Photalgia.Scientific reports · 2018Article
- Treatment of Chronic Migraine with OnabotulinumtoxinA: Mode of Action, Efficacy and Safety.Toxins · 2015Review
- Fathoming the kynurenine pathway in migraine: why understanding the enzymatic cascades is still critically important.Internal and emergency medicine · 2015Review
- Kynurenines and other novel therapeutic strategies in the treatment of dementia.Therapeutic advances in neurological disorders · 2013Article
- Unexpected effects of peripherally administered kynurenic acid on cortical spreading depression and related blood-brain barrier permeability.Drug design, development and therapy · 2013Article
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Migraine is a common, paroxysmal, highly disabling primary headache disorder. The origin of migraine attacks is enigmatic. Numerous clinical and experimental results suggest that the activation of distinct brainstem nuclei is crucial in its pathogenesis, but the primary cause of this activation is not fully understood. We conclude that the initialization of a migraine attack can be explained as an altered function of the neuronal elements of the brainstem nuclei. In light of our findings and the literature data, we can assume that migraine is a subcortical disorder of a specific brainstem area.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.