ArticleInternational journal of colorectal disease2012
Confirmation of three inflammatory bowel disease susceptibility loci in a Chinese cohort.
Article in International journal of colorectal disease, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 2 of them syntheses that pooled it.
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Who cites it
11 citing papers in PubMed, 2 syntheses or guidelines pooled it, 20 citations in OpenAlex.
- Population stratified differences between ATG16L1 rs2241880 polymorphism with Crohn's disease risk: a systematic review and meta-analysis.BMC gastroenterology · 2025Pooled it
- Associations between PTPN2 polymorphisms and susceptibility to ulcerative colitis and Crohn's disease: a meta-analysis.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2014Pooled it
- Bidirectional communication of the gut-brain axis: new findings in Parkinson's disease and inflammatory bowel disease.Frontiers in neurology · 2024Review
- Review
- Genetic associations of inflammatory bowel disease in a South Asian population.World journal of clinical cases · 2018Article
- Functional Variant rs3135500 inFrontiers in aging neuroscience · 2018Article
- Family history and disease outcomes in patients with Crohn's disease: A comparison between China and the United States.World journal of gastrointestinal pharmacology and therapeutics · 2016Article
- Common NOD2/CARD15 and TLR4 Polymorphisms Are Associated with Crohn's Disease Phenotypes in Southeastern Brazilians.Digestive diseases and sciences · 2016Article
- Successful treatment with adalimumab for severe multifocal choroiditis and panuveitis in presumed (early-onset) ocular sarcoidosis.International ophthalmology · 2016Article
- Association between NOD2/CARD15 gene polymorphisms and Crohn's disease in Chinese Zhuang patients.World journal of gastroenterology · 2014Article
- P268S in NOD2 associates with susceptibility to Parkinson's disease in Chinese population.Behavioral and brain functions : BBF · 2013Article
Corrections and comments
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Authors and funding
12 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeRecent genome-wide association studies have identified a number of inflammatory bowel diseases (IBD) susceptibility loci in White populations. The aim of our study was to evaluate whether these susceptibility loci also existed in a Chinese Han IBD population.
methodsPeripheral blood DNA samples from groups of patients with Crohn's disease (CD) (n = 48), ulcerative colitis (UC) (n = 49), and healthy controls (n = 50) were genotyped for eight genes. Then, an extended analysis of the relationship between genotype and phenotype was performed.
resultsNOD2-P268S (P = 0.025) was found to contribute susceptibility to CD in the Chinese population. IL23R-rs11805303 was detected to confer a strong protective effect against UC (P = 0.010), whereas PTPN2-rs2542151 was significantly associated with an increased risk of UC (P = 0.001). Further phenotype-genotype analysis revealed that P268S was associated with early age of onset (P = 0.028), ileal disease (P = 0.003), and enteric cavity narrowing (P = 0.007).
conclusionsThe study indicates that IL23R-rs11805303 and PTPN2-rs2542151 might contribute to the development of UC and NOD2-P268S might be involved in the etiology of CD in the Chinese Han population.
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