ArticleJournal of gastroenterology2012
Patients with chronic hepatitis C express a high percentage of CD4(+)CXCR5(+) T follicular helper cells.
Article in Journal of gastroenterology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
17 citing papers in PubMed, 30 citations in OpenAlex.
- Stepwise differentiation from precursor intermediates and distinct Th1 checkpoints promote CD4 Th1 cell differentiation during chronic viral infection.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Dynamic CD4Nature immunology · 2021Article
- Article
- Chronic Viral Infection Promotes Efficient Germinal Center B Cell Responses.Cell reports · 2020Article
- Follicular helper T cell and memory B cell immunity in CHC patients.Journal of molecular medicine (Berlin, Germany) · 2019Article
- The Transcription Factor T-Bet Is Required for Optimal Type I Follicular Helper T Cell Maintenance During Acute Viral Infection.Frontiers in immunology · 2019Article
- Review
- Type I Interferon in Chronic Virus Infection and Cancer.Trends in immunology · 2017Review
- Overcoming CD4 Th1 Cell Fate Restrictions to Sustain Antiviral CD8 T Cells and Control Persistent Virus Infection.Cell reports · 2016Article
- Interleukin-7 in Patients With Chronic Hepatitis B May Have Effect on T Follicular Helper Cells and Specific Cellular Immunity.Hepatitis monthly · 2016Article
- Type I Interferon Impairs Specific Antibody Responses Early during Establishment of LCMV Infection.Frontiers in immunology · 2016Article
- Innate and Adaptive Immune Regulation During Chronic Viral Infections.Annual review of virology · 2015Review
- T Follicular Helper Cell-Dependent Clearance of a Persistent Virus Infection Requires T Cell Expression of the Histone Demethylase UTX.Immunity · 2015Article
- Abnormal CD4 + T helper (Th) 1 cells and activated memory B cells are associated with type III asymptomatic mixed cryoglobulinemia in HCV infection.Virology journal · 2015Article
- New insights into type I interferon and the immunopathogenesis of persistent viral infections.Current opinion in immunology · 2015Review
- Increased numbers of CD5+CD19+CD1dhighIL-10+ Bregs, CD4+Foxp3+ Tregs, CD4+CXCR5+Foxp3+ follicular regulatory T (TFR) cells in CHB or CHC patients.Journal of translational medicine · 2014Article
- Article
Corrections and comments
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Authors and funding
10 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundT follicular helper (T(FH)) cells are a subpopulation of T-helper cells which regulate humoral immune responses. The role of T(FH) cells in viral infection is unclear. This study examined the possible involvement of CD4(+)CXCR5(+) T(FH) cells in chronic hepatitis C (HCV) infection.
methodsThe percentages of peripheral blood CD4(+)CXCR5(+) T(FH) cells, inducible T-cell costimulator cells, and/or programmed death 1-positive CD4(+)CXCR5(+) T(FH) cells in 39 HCV-infected patients, 12 patients with spontaneously resolved HCV infection (SR-HCV), and 12 healthy controls were characterized by flow cytometry analysis. The subjects' serum HCV RNA loads and alanine aminotransferase and aspartate aminotransferase levels were measured. The potential association of the percentage of peripheral CD4(+)CXCR5(+) T(FH) cells with clinical data was analyzed.
resultsHigher percentages of peripheral blood CD4(+)CXCR5(+) T(FH) cells were found in SR-HCV and HCV-infected patients as compared with healthy controls. Interestingly, a statistically significant negative correlation was found between the percentage of CD4(+)CXCR5(+) T(FH) cells and the HCV RNA load.
conclusionsThese data suggest that CD4(+)CXCR5(+) T(FH) cells may participate in HCV-related immune responses. Increased T(FH) cells in peripheral blood may help to control HCV infection.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.