Evidence map›Paper›PMID 22426566›Full record

ArticlePediatric radiology2012

MRI assessment of bone marrow in children with juvenile idiopathic arthritis: intra- and inter-observer variability.

Laura Tanturri de Horatio, Maria Beatrice Damasio, Domenico Barbuti, Claudia Bracaglia, Karen Lambot-Juhan, Peter Boavida, Lil-Sofie Ording Müller, Clara Malattia, Lucilla Ravà, Karen Rosendahl and 1 more

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Article in Pediatric radiology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
1.2field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 29 citations in OpenAlex.

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4 · The record

Corrections and comments

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5 · Who and what money

Authors and funding

11 authors at 6 institutions in 4 countries.

Laura Tanturri de HoratioDepartment of Radiology, Ospedale Pediatrico Bambino Gesù, Piazza S Onofrio 4, 00165 Rome, Italy. laura.tanturri@opbg.net
Maria Beatrice Damasio
Domenico Barbuti
Claudia Bracaglia
Karen Lambot-Juhan
Peter Boavida
Lil-Sofie Ording Müller
Clara Malattia
Lucilla Ravà
Karen Rosendahl
Paolo Tomà
Bambino Gesù Children's Hospital · ITIstituto Giannina Gaslini · ITHaukeland University Hospital · NOHôpital Necker-Enfants Malades · FRUniversity College London · GBUniversity Hospital of North Norway · NO

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundBone marrow oedema (BMO) is included in MRI-based scoring systems of disease activity in adults with rheumatoid arthritis. Similar systems in juvenile idiopathic arthritis (JIA) are lacking.

objectiveTo assess the reproducibility in a multi-centre setting of an MRI BMO scoring system in children with JIA. MATERIALS AND

methodsSeventy-six wrist MRIs were read twice, independently, by two experienced paediatric radiologists. BMO was defined as ill-defined lesions within the trabecular bone, returning high and low signal on T2- and T1-weighted images respectively, with or without contrast enhancement. BMO extension was scored for each of 14 bones at the wrist from 0 (none) to 3 (extensive).

resultsThe intra-observer agreement was moderate to excellent, with weighted kappa ranging from 0.85 to 1.0 and 0.49 to 1.0 (readers 1 and 2 respectively), while the inter-observer agreement ranged from 0.41 to 0.79. The intra- and inter-observer intraclass correlation coefficients were excellent and satisfactory, respectively.

conclusionThe scoring system was reliable and may be used for grading bone marrow abnormality in JIA. The relatively large variability in aggregate scores, particularly between readers, underscores the need for thorough standardisation.

Indexed as

AdolescentArthritis, JuvenileBone MarrowBone Marrow DiseasesChildChild, PreschoolEdemaFemaleHumansInfantMagnetic Resonance ImagingMaleObserver VariationReproducibility of ResultsSensitivity and Specificity

Identifiers

PMID22426566
OpenAlexW1963695179

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.