ArticleGenes & development2012
A conserved role for COMA/CENP-H/I/N kinetochore proteins in the spindle checkpoint.
Article in Genes & development, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
27 citing papers in PubMed.
- The mFrontiers in oncology · 2025Article
- Pan-Cancer Analysis Reveals CENPI as a Potential Biomarker and Therapeutic Target in Adrenocortical Carcinoma.Journal of inflammation research · 2023Article
- Increased Aurora B expression reduces substrate phosphorylation and induces chromosomal instability.Frontiers in cell and developmental biology · 2022Article
- Review
- Molecular basis for inner kinetochore configuration through RWD domain-peptide interactions.The EMBO journal · 2017Article
- CenpH regulates meiotic G2/M transition by modulating the APC/CCdh1-cyclin B1 pathway in oocytes.Development (Cambridge, England) · 2017Article
- DRG1 is a potential oncogene in lung adenocarcinoma and promotes tumor progression via spindle checkpoint signaling regulation.Oncotarget · 2016Article
- Molecular Circuitry of the SUMO (Small Ubiquitin-like Modifier) Pathway in Controlling Sumoylation Homeostasis and Suppressing Genome Rearrangements.The Journal of biological chemistry · 2016Article
- A Centromere-Signaling Network Underlies the Coordination among Mitotic Events.Trends in biochemical sciences · 2016Review
- Connecting the microtubule attachment status of each kinetochore to cell cycle arrest through the spindle assembly checkpoint.Chromosoma · 2015Review
- CENP-C is a blueprint for constitutive centromere-associated network assembly within human kinetochores.The Journal of cell biology · 2015Article
- Multiple assembly mechanisms anchor the KMN spindle checkpoint platform at human mitotic kinetochores.The Journal of cell biology · 2015Article
- Signalling dynamics in the spindle checkpoint response.Nature reviews. Molecular cell biology · 2014Review
- Article
- CENP-I and Aurora B act as a molecular switch that ties RZZ/Mad1 recruitment to kinetochore attachment status.The Journal of cell biology · 2014Article
- Chk2 prevents mitotic exit when the majority of kinetochores are unattached.The Journal of cell biology · 2014Article
- EB1 enables spindle microtubules to regulate centromeric recruitment of Aurora B.The Journal of cell biology · 2014Article
- Selective disruption of aurora C kinase reveals distinct functions from aurora B kinase during meiosis in mouse oocytes.PLoS genetics · 2014Article
- Accounting for eXentricities: analysis of the X chromosome in GWAS reveals X-linked genes implicated in autoimmune diseases.PloS one · 2014Article
- Review
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
The COMA/CENP-H/I kinetochore complex regulates microtubule dynamics at kinetochores. The complex is also required to generate spindle checkpoint signals in both yeast and human cells under conditions where Aurora B activity is compromised. Our data explain why mammalian cells treated with Aurora inhibitors still have a functional spindle assembly checkpoint (SAC), since the checkpoint signals through CENP-H/I/N. The SAC effect from depleting the CENP-H/I/N complex cannot be explained by a weakened SAC signal, and the complex has no role in the SAC response to paclitaxel. We propose a model to explain the differential response of human cells to nocodazole and paclitaxel.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.