ArticleNature materials2012
Polyvalent choline phosphate as a universal biomembrane adhesive.
Article in Nature materials, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
17 citing papers in PubMed.
- Article
- Intelligent response hydrogel based on choline phosphorylated chitosan programmed repair of infected wounds.Regenerative biomaterials · 2026Article
- Real-TimeAnalytical chemistry · 2025Article
- A self-elastic chitosan sponge integrating active and passive hemostatic mechanisms for effectively managing uncontrolled coagulopathic hemorrhage.Materials today. Bio · 2024Article
- Reversible zwitterionic coordination enables rapid, high-yield, and high-purity isolation of extracellular vesicles from biofluids.Science advances · 2023Article
- Inkjet-Printed Phospholipid Bilayers on Titanium Oxide Surfaces: Towards Functional Membrane Biointerfaces.Membranes · 2022Article
- Enhanced tumour penetration and prolonged circulation in blood of polyzwitterion-drug conjugates with cell-membrane affinity.Nature biomedical engineering · 2021Article
- Tailoring Biomimetic Phosphorylcholine-Containing Block Copolymers as Membrane-Targeting Cellular Rescue Agents.Biomacromolecules · 2019Article
- Zwitterionic Janus Dendrimer with distinct functional disparity for enhanced protein delivery.Biomaterials · 2019Article
- Polyvalent Display of Biomolecules on Live Cells.Angewandte Chemie (International ed. in English) · 2018Article
- Superhydrophobic Natural and Artificial Surfaces-A Structural Approach.Materials (Basel, Switzerland) · 2018Review
- Quantitative SPECT imaging and biodistribution point to molecular weight independent tumor uptake for some long-circulating polymer nanocarriers.RSC advances · 2018Article
- Rapid access to phospholipid analogs using thiol-yne chemistry.Chemical science · 2015Article
- Water-Soluble Polyglycerol Dendrimers with Two Orthogonally Reactive Core Functional Groups for One-Pot Functionalization.Macromolecules · 2015Article
- Zwitteration: coating surfaces with zwitterionic functionality to reduce nonspecific adsorption.Langmuir : the ACS journal of surfaces and colloids · 2014Review
- Lipid nanotechnology.International journal of molecular sciences · 2013Article
- Dendritic polymers: Universal glue for cells.Nature materials · 2012Article
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Authors and funding
9 authors.
Funding
Abstract
Phospholipids in the cell membranes of all eukaryotic cells contain phosphatidyl choline (PC) as the headgroup. Here we show that hyperbranched polyglycerols (HPGs) decorated with the 'PC-inverse' choline phosphate (CP) in a polyvalent fashion can electrostatically bind to a variety of cell membranes and to PC-containing liposomes, the binding strength depending on the number density of CP groups per macromolecule. We also show that HPG-CPs can cause cells to adhere with varying affinity to other cells, and that binding can be reversed by subsequent exposure to low molecular weight HPGs carrying small numbers of PCs. Moreover, PC-rich membranes adsorb and rapidly internalize fluorescent HPG-CP but not HPG-PC molecules, which suggests that HPG-CPs could be used as drug-delivery agents. CP-decorated polymers should find broad use, for instance as tissue sealants and in the self-assembly of lipid nanostructures.
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22426460What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.