ArticleNature neuroscience2012
Netrin (UNC-6) mediates dendritic self-avoidance.
Article in Nature neuroscience, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 56 papers.
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Who cites it
56 citing papers in PubMed, 96 citations in OpenAlex.
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- The kinetochore protein KNL-1 regulates the actin cytoskeleton to control dendrite branching.The Journal of cell biology · 2025Article
- The kpc-1 3'UTR facilitates dendritic transport and translation efficiency of mRNAs for dendrite arborization of a mechanosensory neuron important for male courtship.PLoS genetics · 2024Article
- Dendrite morphogenesis in Caenorhabditis elegans.Genetics · 2024Review
- Optimization of RNAi efficiency in PVD neuron of C. elegans.PloS one · 2024Article
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- The regulatory landscape of neurite development inFrontiers in molecular neuroscience · 2022Review
- Quantitative modeling of regular retinal microglia distribution.Scientific reports · 2021Article
- Tetris in the Nervous System: What Principles of Neuronal Tiling Can Tell Us About How Glia Play the Game.Frontiers in cellular neuroscience · 2021Review
- Chelicerata sDscam isoforms combine homophilic specificities to define unique cell recognition.Proceedings of the National Academy of Sciences of the United States of America · 2020Article
- Deep learning-enabled analysis reveals distinct neuronal phenotypes induced by aging and cold-shock.BMC biology · 2020Article
- Mutually exclusive dendritic arbors in C. elegans neurons share a common architecture and convergent molecular cues.PLoS genetics · 2020Article
- Modular and Distinct Plexin-A4/FARP2/Rac1 Signaling Controls Dendrite Morphogenesis.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2020Article
- [Intrinsic and extrinsic mechanisms regulating neuronal dendrite morphogenesis].Zhejiang da xue xue bao. Yi xue ban = Journal of Zhejiang University. Medical sciences · 2020Review
- Extrinsic Factors Regulating Dendritic Patterning.Frontiers in cellular neuroscience · 2020Review
- Mechanisms that regulate morphogenesis of a highly branched neuron in C. elegans.Developmental biology · 2019Review
- Actin assembly and non-muscle myosin activity drive dendrite retraction in an UNC-6/Netrin dependent self-avoidance response.PLoS genetics · 2019Article
- Microglia exit the CNS in spinal root avulsion.PLoS biology · 2019Article
- Axon-Dependent Patterning and Maintenance of Somatosensory Dendritic Arbors.Developmental cell · 2019Article
- A neuronal MAP kinase constrains growth of a Caenorhabditis elegans sensory dendrite throughout the life of the organism.PLoS genetics · 2018Article
Corrections and comments
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Authors and funding
5 authors at 5 institutions in 1 country.
Funding
Abstract
Dendrites from a single neuron may be highly branched but typically do not overlap. Self-avoidance behavior has been shown to depend on cell-specific membrane proteins that trigger mutual repulsion. Here we report the unexpected discovery that a diffusible cue, the axon guidance protein UNC-6 (Netrin), is required for self-avoidance of sister dendrites from the PVD nociceptive neuron in Caenorhabditis elegans. We used time-lapse imaging to show that dendrites fail to withdraw upon mutual contact in the absence of UNC-6 signaling. We propose a model in which the UNC-40 (Deleted in Colorectal Cancer; DCC) receptor captures UNC-6 at the tips of growing dendrites for interaction with UNC-5 on the apposing branch to induce mutual repulsion. UNC-40 also responds to dendritic contact through another pathway that is independent of UNC-6. Our findings offer a new model for how an evolutionarily conserved morphogenic cue and its cognate receptors can pattern a fundamental feature of dendritic architecture.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.