ArticleNature neuroscience2012
Negative regulation of glial engulfment activity by Draper terminates glial responses to axon injury.
Article in Nature neuroscience, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 61 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
61 citing papers in PubMed.
- Comparative analysis of draper mutant alleles and RNAi expression systems in the ovary and brain of Drosophila melanogaster.G3 (Bethesda, Md.) · 2026Article
- Notch is a ligand of Draper mediating spermatogonia cell death.Nature communications · 2026Article
- Nerve injury promotes glial immune responses through a Draper/Ninjurin A pathway.Neurobiology of disease · 2026Article
- Steroid hormone-dependent glial-neuronal interaction promotes brain development duringbioRxiv : the preprint server for biology · 2025Article
- Adipocyte metabolic state regulates glial phagocytic function.Cell reports · 2025Article
- Molecular profiling of invertebrate glia.Glia · 2025Review
- Article
- Glia control experience-dependent plasticity in an olfactory critical period.bioRxiv : the preprint server for biology · 2024Article
- Galectins induced from hemocytes bridge phosphatidylserine and N-glycosylated Drpr/CED-1 receptor during dendrite pruning.Nature communications · 2024Article
- Impairment of the Glial Phagolysosomal System Drives Prion-Like Propagation in aThe Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Article
- PTPN11/Corkscrew Activates Local Presynaptic Mapk Signaling to Regulate Synapsin, Synaptic Vesicle Pools, and Neurotransmission Strength, with a Dual Requirement in Neurons and Glia.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Article
- Understanding the diversity and dynamics of in vivo efferocytosis: Insights from the fly embryo.Immunological reviews · 2023Review
- Glial Draper signaling triggers cross-neuron plasticity in bystander neurons after neuronal cell death in Drosophila.Nature communications · 2023Article
- Glial Draper signaling triggers cross-neuron plasticity in bystander neurons after neuronal cell death.bioRxiv : the preprint server for biology · 2023Article
- Macrophage subpopulation identity inFrontiers in immunology · 2023Article
- A nerve-wracking buzz: lessons fromFrontiers in aging neuroscience · 2023Review
- The Notch signaling pathway in skeletal muscle health and disease.Muscle & nerve · 2022Review
- Non-autonomous cell death induced by the Draper phagocytosis receptor requires signaling through the JNK and SRC pathways.Journal of cell science · 2022Article
- The phagocytic cyst cells inScience advances · 2022Article
- Insights into nervous system repair from the fruit fly.Neuronal signaling · 2022Review
1 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
Abstract
Neuronal injury elicits potent cellular responses from glia, but molecular pathways modulating glial activation, phagocytic function and termination of reactive responses remain poorly defined. Here we show that positive or negative regulation of glial responses to axon injury is molecularly encoded by unique isoforms of the Drosophila melanogaster engulfment receptor Draper. Draper-I promotes engulfment of axonal debris through an immunoreceptor tyrosine-based activation motif (ITAM). In contrast, Draper-II, an alternative splice variant, potently inhibits glial engulfment function. Draper-II suppresses Draper-I signaling through a previously undescribed immunoreceptor tyrosine-based inhibitory motif (ITIM)-like domain and the tyrosine phosphatase Corkscrew (Csw). Intriguingly, loss of Draper-II-Csw signaling prolongs expression of glial engulfment genes after axotomy and reduces the ability of glia to respond to secondary axotomy. Our work highlights a novel role for Draper-II in inhibiting glial responses to neurodegeneration, and indicates that a balance of opposing Draper-I and Draper-II signaling events is essential to maintain glial sensitivity to brain injury.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.