ArticleNature communications2012
Three-dimensional imaging of single nanotube molecule endocytosis on plasmonic substrates.
Article in Nature communications, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
21 citing papers in PubMed.
- The protein corona at the nano-bio interface: the need for standardized methodology and opportunities for neurodegenerative disease intervention.RSC advances · 2026Review
- Mesoporous Silica Nanoparticles-Based Formulations for Enhanced Oral Delivery of Peptide Drugs: A Case Study on Insulin.Small (Weinheim an der Bergstrasse, Germany) · 2026Article
- High-Speed, Pixel-Super-resolved Compressive Second Near-Infrared Fluorescence In Vivo Imaging.Research (Washington, D.C.) · 2026Article
- Revolutionizing lymph node metastasis imaging: the role of drug delivery systems and future perspectives.Journal of nanobiotechnology · 2024Review
- Loading and release of cancer chemotherapy drugs utilizing simultaneous temperature and pH-responsive nanohybrid.BMC pharmacology & toxicology · 2021Article
- Carbon Nanomaterials for Sorption ofNanomaterials (Basel, Switzerland) · 2020Article
- Optical Properties of Electrically Active Gold Nanoisland Films Enabled with Interfaced Liquid Crystals.Nanomaterials (Basel, Switzerland) · 2020Article
- Article
- Contrast improvement in indocyanine green fluorescence sensing in thick tissue using a time-gating method.Biomedical optics express · 2019Article
- Advances in Nanomaterials for Brain Microscopy.Nano research · 2018Article
- Multifunctional biomedical imaging in physiological and pathological conditions using a NIR-II probe.Advanced functional materials · 2017Article
- Discovery of a Biological Mechanism of Active Transport through the Tympanic Membrane to the Middle Ear.Scientific reports · 2016Article
- Cell Membrane Proteins Modulate the Carbon Nanotube Optical Bandgap via Surface Charge Accumulation.ACS nano · 2016Article
- Recent Progress in Light-Triggered Nanotheranostics for Cancer Treatment.Theranostics · 2016Review
- Fluorescent imaging of cancerous tissues for targeted surgery.Advanced drug delivery reviews · 2014Review
- Through-skull fluorescence imaging of the brain in a new near-infrared window.Nature photonics · 2014Article
- Bioorthogonal, two-component delivery systems based on antibody and drug-loaded nanocarriers for enhanced internalization of nanotherapeutics.Biomaterials · 2014Article
- Sequential administration of carbon nanotubes and near-infrared radiation for the treatment of gliomas.Frontiers in oncology · 2014Article
- An integrated peptide-antigen microarray on plasmonic gold films for sensitive human antibody profiling.PloS one · 2013Article
- Multifunctional in vivo vascular imaging using near-infrared II fluorescence.Nature medicine · 2012Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
Abstract
Investigating the cellular internalization pathways of single molecules or single nano objects is important to understanding cell-matter interactions, and to applications in drug delivery and discovery. Imaging and tracking the motion of single molecules on cell plasma membranes require high spatial resolution in three dimensions. Fluorescence imaging along the axial dimension with nanometre resolution has been highly challenging, but critical to revealing displacements in transmembrane events. Here, utilizing a plasmonic ruler based on the sensitive distance dependence of near-infrared fluorescence enhancement of carbon nanotubes on a gold plasmonic substrate, we probe ~10 nm scale transmembrane displacements through changes in nanotube fluorescence intensity, enabling observations of single nanotube endocytosis in three dimensions. Cellular uptake and transmembrane displacements show clear dependences to temperature and clathrin assembly on cell membrane, suggesting that the cellular entry mechanism for a nanotube molecule is via clathrin-dependent endocytosis through the formation of clathrin-coated pits on the cell membrane.
Indexed as
Identifiers
22426221What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.