ArticleNature communications2012
New insights into the Tyrolean Iceman's origin and phenotype as inferred by whole-genome sequencing.
Article in Nature communications, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 187 papers.
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Who cites it
187 citing papers in PubMed, 458 citations in OpenAlex.
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- Graph transformer for ancient ancestry inference.bioRxiv : the preprint server for biology · 2026Article
- Peptidoglycan architecture dictates protein interactions, tissue tropism, and arthritis in the Lyme disease spirochete Borrelia burgdorferi.PLoS pathogens · 2026Article
- The genomic footprints of migration: how ancient DNA reveals our history of mobility.Genome biology · 2025Review
- Genomic diversity and structure of prehistoric alpine individuals from the Tyrolean Iceman's territory.Nature communications · 2025Article
- Sequencing and characterizing human mitochondrial genomes in the biobank-based genomic research paradigm.Science China. Life sciences · 2025Review
- Urbanization and genetic homogenization in the medieval Low Countries revealed through a ten-century paleogenomic study of the city of Sint-Truiden.Genome biology · 2025Article
- Cost-effectiveness and other considerations for different research techniques applied in ancient DNA analysis.Anatomy & cell biology · 2025Review
- The Allen Ancient DNA Resource (AADR) a curated compendium of ancient human genomes.Scientific data · 2024Article
- Article
- Genetic Predisposition of Atherosclerotic Cardiovascular Disease in Ancient Human Remains.Annals of global health · 2024Article
- Ancestry and kinship in a Late Antiquity-Early Middle Ages cemetery in the Eastern Italian Alps.iScience · 2023Article
- High-coverage genome of the Tyrolean Iceman reveals unusually high Anatolian farmer ancestry.Cell genomics · 2023Article
- Bioarchaeological and paleogenomic profiling of the unusual Neolithic burial from Grotta di Pietra Sant'Angelo (Calabria, Italy).Scientific reports · 2023Article
- Revealing Joseon period People's single nucleotide polymorphism associated with lactase gene by ancient DNA analysis of human remains from archaeological sites in Korea.Anatomy & cell biology · 2023Article
- Review
- Morphological and Tissue Characterization with 3D Reconstruction of a 350-Year-Old AustrianBiology · 2023Article
- Systemic lupus erythematosus and cardiovascular disease.Journal of internal medicine · 2023Review
127 more citing papers are in PubMed but not listed here.
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Authors and funding
41 authors at 15 institutions in 8 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The Tyrolean Iceman, a 5,300-year-old Copper age individual, was discovered in 1991 on the Tisenjoch Pass in the Italian part of the Ötztal Alps. Here we report the complete genome sequence of the Iceman and show 100% concordance between the previously reported mitochondrial genome sequence and the consensus sequence generated from our genomic data. We present indications for recent common ancestry between the Iceman and present-day inhabitants of the Tyrrhenian Sea, that the Iceman probably had brown eyes, belonged to blood group O and was lactose intolerant. His genetic predisposition shows an increased risk for coronary heart disease and may have contributed to the development of previously reported vascular calcifications. Sequences corresponding to ~60% of the genome of Borrelia burgdorferi are indicative of the earliest human case of infection with the pathogen for Lyme borreliosis.
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