ArticleThe EMBO journal2012
Organismal propagation in the absence of a functional telomerase pathway in Caenorhabditis elegans.
Article in The EMBO journal, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
17 citing papers in PubMed, 27 citations in OpenAlex.
- ATRX safeguards cellular identity duringbioRxiv : the preprint server for biology · 2026Article
- The leaves fall, yet the tree endures.Cellular and molecular life sciences : CMLS · 2025Review
- TERRA expression is regulated by the telomere-binding proteins POT-1 and POT-2 in Caenorhabditis elegans.Nucleic acids research · 2023Article
- Distinct characteristics of two types of alternative lengthening of telomeres in mouse embryonic stem cells.Nucleic acids research · 2023Article
- The double-stranded DNA-binding proteins TEBP-1 and TEBP-2 form a telomeric complex with POT-1.Nature communications · 2021Article
- The Telomere Paradox: Stable Genome Preservation with Rapidly Evolving Proteins.Trends in genetics : TIG · 2020Review
- TRF1 phosphorylation on T271 modulates telomerase-dependent telomere length maintenance as well as the formation of ALT-associated PML bodies.Scientific reports · 2016Article
- Paradoxical delay of senescence upon depletion of BRCA2 in telomerase-deficient worms.FEBS open bio · 2016Article
- Molecular mechanisms of activity and derepression of alternative lengthening of telomeres.Nature structural & molecular biology · 2015Review
- Telomere maintenance through recruitment of internal genomic regions.Nature communications · 2015Article
- Unique C. elegans telomeric overhang structures reveal the evolutionarily conserved properties of telomeric DNA.Nucleic acids research · 2015Article
- Telomere elongation chooses TERRA ALTernatives.RNA biology · 2015Review
- If the cap fits, wear it: an overview of telomeric structures over evolution.Cellular and molecular life sciences : CMLS · 2014Review
- The shelterin protein POT-1 anchors Caenorhabditis elegans telomeres through SUN-1 at the nuclear periphery.The Journal of cell biology · 2013Article
- Caenorhabditis elegans POT-1 and POT-2 repress telomere maintenance pathways.G3 (Bethesda, Md.) · 2013Article
- C. elegans survivors without telomerase.Worm · 2013Article
- Article
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 2 countries.
Funding
Abstract
To counteract replication-dependent telomere shortening most eukaryotic cells rely on the telomerase pathway, which is crucial for the maintenance of proliferative potential of germ and stem cell populations of multicellular organisms. Likewise, cancer cells usually engage the telomerase pathway for telomere maintenance to gain immortality. However, in ∼10% of human cancers telomeres are maintained through telomerase-independent alternative lengthening of telomeres (ALT) pathways. Here, we describe the generation and characterization of C. elegans survivors in a strain lacking the catalytic subunit of telomerase and the nematode telomere-binding protein CeOB2. These clonal strains, some of which have been propagated for >180 generations, represent the first example of a multicellular organism with canonical telomeres that can survive without a functional telomerase pathway. The animals display the heterogeneous telomere length characteristic for ALT cells, contain single-stranded C-circles, a transcription profile pointing towards an adaptation to chronic stress and are therefore a unique and valuable tool to decipher the ALT mechanism.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.