ArticleNeuroImage2012
Detection of calcifications in vivo and ex vivo after brain injury in rat using SWIFT.
Article in NeuroImage, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
22 citing papers in PubMed, 42 citations in OpenAlex.
- A Sub-Microsecond Switch Enabling SWIFTMagnetic resonance in medicine · 2026Article
- Secondary thalamic neuroinflammation associates with disturbed corticothalamic connectivity in a model of severe traumatic brain injury in male rats-a longitudinal study.Cerebral cortex (New York, N.Y. : 1991) · 2026Article
- Article
- Diffusion MRI approaches for investigating microstructural complexity in a rat model of traumatic brain injury.Scientific reports · 2023Article
- Zero-TE MRI: principles and applications in the head and neck.The British journal of radiology · 2022Review
- Article
- Quantitative synchrotron X-ray tomography of the material-tissue interface in rat cortex implanted with neural probes.Scientific reports · 2019Article
- Imaging biomarkers of epileptogenecity after traumatic brain injury - Preclinical frontiers.Neurobiology of disease · 2019Review
- MRS Reveals Chronic Inflammation in T2w MRI-Negative Perilesional Cortex - A 6-Months Multimodal Imaging Follow-Up Study.Frontiers in neuroscience · 2019Article
- Nuclei-specific deposits of iron and calcium in the rat thalamus after status epilepticus revealed with quantitative susceptibility mapping (QSM).Journal of magnetic resonance imaging : JMRI · 2018Article
- Positive contrast from cells labeled with iron oxide nanoparticles: Quantitation of imaging data.Magnetic resonance in medicine · 2017Article
- Full analytical solution of the bloch equation when using a hyperbolic-secant driving function.Magnetic resonance in medicine · 2017Article
- Gradient-modulated SWIFT.Magnetic resonance in medicine · 2016Article
- Quantitative MR Markers and Psychiatric Symptoms in a Patient with Fahr Disease.The American journal of case reports · 2015Article
- SWIFT MRI enhances detection of breast cancer metastasis to the lung.Magnetic resonance in medicine · 2015Article
- Phase imaging in brain using SWIFT.Journal of magnetic resonance (San Diego, Calif. : 1997) · 2015Article
- Diffusion tensor imaging detects chronic microstructural changes in white and gray matter after traumatic brain injury in rat.Frontiers in neuroscience · 2015Article
- Improved Visualization of Cartilage Canals Using Quantitative Susceptibility Mapping.PloS one · 2015Article
- Ultrashort echo time (UTE) imaging of receptor targeted magnetic iron oxide nanoparticles in mouse tumor models.Journal of magnetic resonance imaging : JMRI · 2014Article
- T₁ estimation for aqueous iron oxide nanoparticle suspensions using a variable flip angle SWIFT sequence.Magnetic resonance in medicine · 2013Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 3 institutions in 2 countries.
Funding
Abstract
Calcifications represent one component of pathology in many brain diseases. With MRI, they are most often detected by exploiting negative contrast in magnitude images. Calcifications are more diamagnetic than tissue, leading to a magnetic field disturbance that can be seen in phase MR images. Most phase imaging studies use gradient recalled echo based pulse sequences. Here, the phase component of SWIFT, a virtually zero acquisition delay sequence, was used to detect calcifications ex vivo and in vivo in rat models of status epilepticus and traumatic brain injury. Calcifications were detected in phase and imaginary SWIFT images based on their dipole like magnetic field disturbances. In magnitude SWIFT images, calcifications were distinguished as hypointense and hyperintense. Hypointense calcifications showed large crystallized granules with few surrounding inflammatory cells, while hyperintense calcifications contained small granules with the presence of more inflammatory cells. The size of the calcifications in SWIFT magnitude images correlated with that in Alizarin stained histological sections. Our data indicate that SWIFT is likely to better preserve signal in the proximity of a calcification or other field perturber in comparison to gradient echo due to its short acquisition delay and broad excitation bandwidth. Furthermore, a quantitative description for the phase contrast near dipole magnetic field inhomogeneities for the SWIFT pulse sequence is given. In vivo detection of calcifications provides a tool to probe the progression of pathology in neurodegenerative diseases. In particular, it appears to provide a surrogate marker for inflammatory cells around the calcifications after brain injury.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.