ArticleDevelopmental biology2012
Specific domains of FoxD4/5 activate and repress neural transcription factor genes to control the progression of immature neural ectoderm to differentiating neural plate.
Article in Developmental biology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 29 citations in OpenAlex.
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- Loss ofFrontiers in cell and developmental biology · 2021Article
- Mcrs1 interacts with Six1 to influence early craniofacial and otic development.Developmental biology · 2020Article
- Natural size variation among embryos leads to the corresponding scaling in gene expression.Developmental biology · 2020Article
- FOXD3/FOXD4 is required for the development of hindgut in the rat model of anorectal malformation.Experimental biology and medicine (Maywood, N.J.) · 2018Article
- FOXD4 induces tumor progression in colorectal cancer by regulation of the SNAI3/CDH1 axis.Cancer biology & therapy · 2018Article
- Wbp2nl has a developmental role in establishing neural and non-neural ectodermal fates.Developmental biology · 2017Article
- Foxd4 is essential for establishing neural cell fate and for neuronal differentiation.Genesis (New York, N.Y. : 2000) · 2017Article
- Differential gene expression along the animal-vegetal axis in the ascidian embryo is maintained by a dual functional protein Foxd.PLoS genetics · 2017Article
- Dual roles of Akirin2 protein duringThe Journal of biological chemistry · 2017Article
- Pa2G4 is a novel Six1 co-factor that is required for neural crest and otic development.Developmental biology · 2017Article
- Neural transcription factors bias cleavage stage blastomeres to give rise to neural ectoderm.Genesis (New York, N.Y. : 2000) · 2016Article
- Transcriptional regulatory events initiated by Ascl1 and Neurog2 during neuronal differentiation of P19 embryonic carcinoma cells.Journal of molecular neuroscience : MN · 2015Article
- Neural transcription factors: from embryos to neural stem cells.Molecules and cells · 2014Review
- On becoming neural: what the embryo can tell us about differentiating neural stem cells.American journal of stem cells · 2013Article
- Conserved structural domains in FoxD4L1, a neural forkhead box transcription factor, are required to repress or activate target genes.PloS one · 2013Article
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
FoxD4/5, a forkhead transcription factor, plays a critical role in establishing and maintaining the embryonic neural ectoderm. It both up-regulates genes that maintain a proliferative, immature neural ectoderm and down-regulates genes that promote the transition to a differentiating neural plate. We constructed deletion and mutant versions of FoxD4/5 to determine which domains are functionally responsible for these opposite activities, which regulate the critical developmental transition of neural precursors to neural progenitors to differentiating neural plate cells. Our results show that up-regulation of genes that maintain immature neural precursors (gem, zic2) requires the Acidic blob (AB) region in the N-terminal portion of the protein, indicating that the AB is the transactivating domain. Additionally, down-regulation of those genes that promote the transition to neural progenitors (sox) and those that lead to neural differentiation (zic, irx) involves: 1) an interaction with the Groucho co-repressor at the Eh-1 motif in the C-terminus; and 2) sequence downstream of this motif. Finally, the ability of FoxD4/5 to induce the ectopic expression of neural precursor genes in the ventral ectoderm also involves both the AB region and the Eh-1 motif; FoxD4/5 accomplishes ectopic neural induction by both activating neural precursor genes and repressing BMP signaling and epidermal genes. This study identifies the specific, conserved domains of the FoxD4/5 protein that allow this single transcription factor to regulate a network of genes that controls the transition of a proliferative neural ectodermal population to a committed neural plate population poised to begin differentiation.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.