Evidence map›Paper›PMID 22425612›Full record

ReviewAdvanced drug delivery reviews2012

Self-folding polymeric containers for encapsulation and delivery of drugs.

Rohan Fernandes, David H Gracias

Abstract readReview
In one paragraph

Review in Advanced drug delivery reviews, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers.

0numbers the graph read from it
0cells of the map it votes in
37citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

37 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. FromMaterials today. Bio · 2025
    Review
  5. Article
  6. Tunable wave coupling in periodically rotated Miura-ori tubes.Philosophical transactions. Series A, Mathematical, physical, and engineering sciences · 2024
    Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Review
  12. Article
  13. Article
  14. Compressive Buckling Fabrication of 3D Cell-Laden Microstructures.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2021
    Article
  15. Article
  16. Lattice model for self-folding at the microscale.The European physical journal. E, Soft matter · 2021
    Article
  17. Biomedical nanoparticle design: What we can learn from viruses.Journal of controlled release : official journal of the Controlled Release Society · 2021
    Review
  18. Active matter therapeutics.Nano today · 2020
    Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Rohan FernandesDepartment of Chemical and Biomolecular Engineering, Johns Hopkins University, 3400 N Charles Street, Baltimore, MD 21218, USA.
David H Gracias

Funding

Minimally Invasive Micro-Nanoscale Tools and Devices for MedicineDP2OD004346 · OD · JOHNS HOPKINS UNIVERSITY · PI GRACIAS, DAVID H · 2008 to 2009
$2.5M
NIH HHS 1-DP2-OD004346-01NIH HHS DP2 OD004346
6 · The paper itself

Abstract

Self-folding broadly refers to self-assembly processes wherein thin films or interconnected planar templates curve, roll-up or fold into three dimensional (3D) structures such as cylindrical tubes, spirals, corrugated sheets or polyhedra. The process has been demonstrated with metallic, semiconducting and polymeric films and has been used to curve tubes with diameters as small as 2nm and fold polyhedra as small as 100nm, with a surface patterning resolution of 15nm. Self-folding methods are important for drug delivery applications since they provide a means to realize 3D, biocompatible, all-polymeric containers with well-tailored composition, size, shape, wall thickness, porosity, surface patterns and chemistry. Self-folding is also a highly parallel process, and it is possible to encapsulate or self-load therapeutic cargo during assembly. A variety of therapeutic cargos such as small molecules, peptides, proteins, bacteria, fungi and mammalian cells have been encapsulated in self-folded polymeric containers. In this review, we focus on self-folding of all-polymeric containers. We discuss the mechanistic aspects of self-folding of polymeric containers driven by differential stresses or surface tension forces, the applications of self-folding polymers in drug delivery and we outline future challenges.

Indexed as

Drug Delivery SystemsPharmaceutical PreparationsPolymersPharmaceutical PreparationsPolymers

Identifiers

PMID22425612
PMCPMC3462897

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.