ArticleBiological psychiatry2012
Vascular risk status as a predictor of later-life depressive symptoms: a cohort study.
Article in Biological psychiatry, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed.
- Associations of Midlife Vascular Risk Factors With Late-Life Depressive Symptoms: Findings From the ARIC Study.Journal of the American Heart Association · 2026Article
- The Impact of Anxiety and Depression on Health-Related Quality of Life in Hyperlipidemic Adults in the United States.Journal of clinical medicine · 2025Article
- Association of mental health in childhood, adolescence and young adulthood with cardiovascular risk factors and carotid remodeling below age 30 - results from the KiGGS cohort study.European journal of epidemiology · 2025Article
- Mediation of the Association Between Vascular Risk Factors and Depressive Symptoms by C-Reactive Protein.Biological psychiatry global open science · 2023Article
- Is later-life depression a risk factor for Alzheimer's disease or a prodromal symptom: a study using post-mortem human brain tissue?Alzheimer's research & therapy · 2023Article
- Associations between mental health, blood pressure and the development of hypertension.Nature communications · 2023Article
- Mental and physical health pathways linking insomnia symptoms to cognitive performance 14 years later.Sleep · 2023Article
- The Age-Dependent Association Between Vascular Risk Factors and Depressed Mood.The journals of gerontology. Series B, Psychological sciences and social sciences · 2022Article
- Immune dysregulation in depression: Evidence from genome-wide association.Brain, behavior, & immunity - health · 2020Article
- Cognition and the Predictive Utility of Three Risk Scores in an Ethnically Diverse Sample.Journal of Alzheimer's disease : JAD · 2020Article
- Allostatic load as a predictor of grey matter volume and white matter integrity in old age: The Whitehall II MRI study.Scientific reports · 2018Article
- Coronary heart disease and risk factors as predictors of trajectories of psychological distress from midlife to old age.Heart (British Cardiac Society) · 2017Article
- Uncoupling protein 2 haplotype does not affect human brain structure and function in a sample of community-dwelling older adults.PloS one · 2017Article
- Effects of Endurance Exercise Modalities on Arterial Stiffness in Patients Suffering from Unipolar Depression: A Randomized Controlled Trial.Frontiers in psychiatry · 2017Article
- Integrating affective and cognitive correlates of heart rate variability: A structural equation modeling approach.International journal of psychophysiology : official journal of the International Organization of Psychophysiology · 2015Article
- Midlife stroke risk and cognitive decline: a 10-year follow-up of the Whitehall II cohort study.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2013Article
- Cardiovascular disease risk scores in identifying future frailty: the Whitehall II prospective cohort study.Heart (British Cardiac Society) · 2013Article
- Predicting cognitive decline: a dementia risk score vs. the Framingham vascular risk scores.Neurology · 2013Article
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Authors and funding
9 authors.
Funding
Abstract
backgroundCommon etiology of vascular diseases and later-life depression may provide important synergies for prevention. We examined whether standard clinical risk profiles developed for vascular diseases also predict depressive symptoms in older adults.
methodsData were drawn from the Whitehall II study with baseline examination in 1991; follow-up screenings in 1997, 2003, and 2008; and additional disease ascertainment from hospital data and registry linkage on 5318 participants (mean age 54.8 years, 31% women) without depressive symptoms at baseline. Vascular risk was assessed with the Framingham Cardiovascular, Coronary Heart Disease, and Stroke Risk Scores. New depressive symptoms at each follow-up screening were identified by General Health Questionnaire caseness, a Center for Epidemiologic Studies Depression Scale score ≥16, and use of antidepressant medication.
resultsDiagnosed vascular disease (that is, coronary heart disease or stroke) was associated with an increased risk for depressive symptoms, age- and sex-adjusted odds ratios from 1.5 (95% confidence interval 1.0-2.2) to 2.0 (1.4-3.0), depending on the indicator of depressive symptoms. Among participants without manifest vascular disease, the Stroke Risk Score was associated with Center for Epidemiologic Studies Depression Scale depressive symptoms before age 65 (age- and sex-adjusted odds ratio per 10% absolute change in the score = 3.1 [1.5-6.5]), but none of the risk scores predicted new-onset depressive symptoms in those aged ≥65 (odds ratios from .8 to 1.2).
conclusionsThese data suggest that public health measures to improve vascular risk status will influence the incidence of later-life depressive symptoms via reduced rates of manifest vascular disease.
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