Trial reportDrug and alcohol dependence2012
A stage I pilot study of acceptance and commitment therapy for methadone detoxification.
Trial report in Drug and alcohol dependence, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05039554 (Randomized Trial of Acceptance and Commitment Therapy), which is not on this map. Cited by 23 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Randomized Trial of Acceptance and Commitment Therapy (ACT) and a Care Management App in Primary Care-based Buprenorphine Treatment
Who cites it
23 citing papers in PubMed, 3 syntheses or guidelines pooled it, 77 citations in OpenAlex.
- Evaluating comparative effect of non-pharmacological interventions adjunctive to opioid agonist therapy for opioid use disorder: A systematic review with network meta-analysis.Addiction (Abingdon, England) · 2026Pooled it
- Methadone at tapered doses for the management of opioid withdrawal.The Cochrane database of systematic reviews · 2013Pooled it
- A Systematic Review on the Use of Psychosocial Interventions in Conjunction With Medications for the Treatment of Opioid Addiction.Journal of addiction medicinePooled it
- A preliminary randomized controlled trial of a distress tolerance treatment for opioid dependent persons initiating buprenorphine.Drug and alcohol dependence · 2015Trial
- Opioid withdrawal, craving, and use during and after outpatient buprenorphine stabilization and taper: a discrete survival and growth mixture model.Addictive behaviors · 2015Trial
- Barriers and motivators for opioid deprescribing among Danish adults receiving long-term treatment with short-acting opioids: an exploratory qualitative study in primary care informed by self-determination theory.Scandinavian journal of primary health care · 2026Article
- Persisting with Purpose: Using Acceptance and Commitment Therapy to Target Comorbid Opioid Use Disorder and Chronic Pain in a Racially and Economically Marginalized Population.Journal of contextual behavioral science · 2025Article
- Integrative cognitive neuropsychological program emphasizing brain response to enhance inhibitory control among substance abusers at the alternative rehabilitation communities in Eastern Thailand.Frontiers in psychiatry · 2025Article
- A Randomized Trial Evaluating Acceptance and Commitment Therapy and Smart Phone Care Management Application to Augment Buprenorphine Therapy for Opioid Use and Chronic Pain.Substance use & addiction journal · 2025Article
- Abstinence phobia among adult African American/Black cannabis users.Addictive behaviors · 2022Article
- Goofballing of Opioid and Methamphetamine: The Science Behind the Deadly Cocktail.Frontiers in pharmacology · 2022Review
- A Personalized, Interactive, Cognitive Behavioral Therapy-Based Digital Therapeutic (MODIA) for Adjunctive Treatment of Opioid Use Disorder: Development Study.JMIR mental health · 2021Article
- A Narrative Review of Third-Wave Cognitive-Behavioral Therapies in Addiction.Addiction & health · 2021Review
- The Use of Acceptance and Commitment Therapy in Substance Use Disorders: A Review of Literature.Journal of clinical medicine research · 2020Review
- Psychological Flexibility and Depression in New Mothers of Medically Vulnerable Infants: A Mediational Analysis.Maternal and child health journal · 2019Article
- Analgesic reduction during an interdisciplinary pain management programme: treatment effects and processes of change.British journal of pain · 2018Article
- A sequential multiple assignment randomized trial for cocaine cessation and relapse prevention: Tailoring treatment to the individual.Contemporary clinical trials · 2018Article
- The psychology of chronic post-surgical pain: new frontiers in risk factor identification, prevention and management.British journal of pain · 2017Article
- A contextual model of self-regulation change mechanisms among individuals with addictive disorders.Clinical psychology review · 2017Review
- The Need for Psychosocial Interventions to Facilitate the Transition to Extended-Release Naltrexone (XR-NTX) Treatment for Opioid Dependence: A Concise Review of the Literature.Substance abuse : research and treatment · 2016Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 3 institutions in 1 country.
Funding
Abstract
backgroundWhile agonist replacement therapies are effective for managing opioid dependence, community treatment programs are increasingly choosing detoxification. Unfortunately, success rates for opioid detoxification are very low, in part, due to physical and psychological symptoms associated with opioid withdrawal. Few behavior therapies specifically address the distressing experiences specific to opioid withdrawal. A novel behavioral treatment, acceptance and commitment therapy (ACT), works from the premise that the avoidance of unpleasant private experiences (thoughts, feelings, bodily sensations) is ubiquitous yet may be pathogenic, resulting in treatment drop-out and further drug use.
methodsThis Stage I pilot study developed and tested an ACT-based opioid detoxification behavioral therapy. Opioid dependent patients (N=56) who were attending a licensed methadone clinic were randomized to receive either 24 individual therapy sessions of ACT or drug counseling (DC) in the context of a 6-month methadone dose reduction program.
resultsWhile no difference was found on opioid use during treatment, 37% of participants in the ACT condition were successfully detoxified at the end of treatment compared to 19% of those who received DC. Fear of detoxification was also reduced across time in the ACT condition relative to DC.
conclusionThis first study of ACT to assist opioid detoxification indicates promise. Research is needed to refine specific treatment strategies for this population to further strengthen effects.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.