Trial reportGastrointestinal endoscopy2012
Feasibility, safety, acceptability, and yield of office-based, screening transnasal esophagoscopy (with video).
Trial report in Gastrointestinal endoscopy, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 55 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
55 citing papers in PubMed, 3 syntheses or guidelines pooled it, 114 citations in OpenAlex.
- Diagnostic and Clinical Performance of Single-Use Versus Reusable Gastrointestinal Endoscopes: A Systematic Review and Meta-Analyses.Journal of gastroenterology and hepatology · 2026Pooled it
- Unsedated transnasal endoscopy for the detection of Barrett's esophagus: systematic review and meta-analysis.Diseases of the esophagus : official journal of the International Society for Diseases of the Esophagus · 2023Pooled it
- ACG Clinical Guideline: Diagnosis and Management of Barrett's Esophagus.The American journal of gastroenterology · 2016Guideline
- Trial
- A randomized comparative effectiveness trial of novel endoscopic techniques and approaches for Barrett's esophagus screening in the community.The American journal of gastroenterology · 2015Trial
- Comparative acceptability of transnasal esophagoscopy and esophageal capsule esophagoscopy: a randomized, controlled trial in veterans.Gastrointestinal endoscopy · 2014Trial
- Screening for Barrett's esophagus: results from a population-based survey.Digestive diseases and sciences · 2014Trial
- Pathologies Detected Using In-Office Transnasal Oesophagoscopy: Our Cohort of 234 Cases.Clinical otolaryngology : official journal of ENT-UK ; official journal of Netherlands Society for Oto-Rhino-Laryngology & Cervico-Facial Surgery · 2026Article
- Sliding hiatal hernia detected by transnasal esophagogastroscopy is associated with poorer treatment response in reflux-associated globus sensation.Scientific reports · 2026Article
- New Approaches to Screening for Barrett Esophagus.Gastroenterology & hepatology · 2025Article
- Comparison of clinical nasal endoscopy, optical biopsy, and artificial intelligence in early diagnosis and treatment planning in laryngeal cancer: a prospective observational study.Frontiers in oncology · 2025Article
- Pediatric unsedated transnasal endoscopy: applications, equipment, and future directions.Frontiers in pediatrics · 2025Review
- Change in Symptoms and Mucosal Findings after Proton Pump Inhibitor in Patients with Laryngopharyngeal Reflux.International archives of otorhinolaryngology · 2025Article
- [Use of flexible transnasal esophagogastroscopy in patients with unclear globus sensation].HNO · 2024Article
- Development and validation of a novel risk prediction algorithm to estimate 10-year risk of oesophageal cancer in primary care: prospective cohort study and evaluation of performance against two other risk prediction models.The Lancet regional health. Europe · 2023Article
- New Techniques to Screen for Barrett Esophagus.Gastroenterology & hepatology · 2023Article
- Visibility of early gastric cancers by texture and color enhancement imaging using a high-definition ultrathin transnasal endoscope.Scientific reports · 2023Article
- Public acceptance and uptake of oesophageal adenocarcinoma screening strategies: A mixed-methods systematic review.EClinicalMedicine · 2022Article
- Innovations in Screening Tools for Barrett's Esophagus and Esophageal Adenocarcinoma.Current gastroenterology reports · 2021Review
- Advances in optical gastrointestinal endoscopy: a technical review.Molecular oncology · 2021Review
Corrections and comments
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Authors and funding
16 authors at 4 institutions in 1 country.
Funding
Abstract
backgroundEndoscopic screening for esophageal neoplasia can identify patients eligible for early intervention for precancerous lesions. Unsedated transnasal esophagoscopy may provide an efficient and accurate endoscopic assessment with fewer risks and less cost, compared with conventional upper endoscopy.
objectiveTo assess the feasibility, safety, acceptability, and yield of unsedated transnasal esophagoscopy in a primary care population.
designMulticenter, prospective, cross-sectional study.
settingTwo outpatient tertiary-care centers. PATIENTS: This study involved a general medical clinic population aged between 40 and 85 years.
interventionUnsedated, office-based transnasal esophagoscopy. MAIN OUTCOME MEASUREMENTS: Procedure yield; completeness of examination; procedure length; adverse events and complications; choking, gagging, pain, or anxiety during the examination; and overall tolerability.
resultsA total of 426 participants (mean [± standard deviation] age 55.8 ± 9.5 years; 43% male) enrolled in the study, and 422 (99%) completed the examination. Mean (± standard deviation) examination time was 3.7 ± 1.8 minutes. There were no serious adverse events, and 12 participants (2.8%) reported minor complications. Participants reported minimal choking, gagging, pain, or anxiety. The examination was well-tolerated by most participants. Overall, 38% of participants had an esophageal finding that changed management (34% erosive esophagitis, 4% Barrett's esophagus). LIMITATIONS: Nonrandomized study, tertiary-care centers only, self-selected population with a large proportion reporting esophageal symptoms.
conclusionUnsedated transnasal esophagoscopy is a feasible, safe, and well-tolerated method to screen for esophageal disease in a primary care population. Endoscopic findings are common in this patient population.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.