ArticleCurrent biology : CB2012
Transient structure associated with the spindle pole body directs meiotic microtubule reorganization in S. pombe.
Article in Current biology : CB, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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22 citing papers in PubMed, 35 citations in OpenAlex.
- Constitutively active RAS prolongs Cdc42 signalling, while MAPK signalling is attenuated during fission yeast mating.PLoS genetics · 2026Article
- A force balance model for a cell size-dependent meiotic nuclear oscillation in fission yeast.EMBO reports · 2023Article
- Beyond tradition: exploring the non-canonical functions of telomeres in meiosis.Frontiers in cell and developmental biology · 2023Article
- Rec8 Cohesin-mediated Axis-loop chromatin architecture is required for meiotic recombination.Nucleic acids research · 2022Article
- An extended DNA-free intranuclear compartment organizes centrosome microtubules in malaria parasites.Life science alliance · 2021Article
- Tell the Difference Between Mitosis and Meiosis: Interplay Between Chromosomes, Cytoskeleton, and Cell Cycle Regulation.Frontiers in cell and developmental biology · 2021Review
- Genes Important forGenetics · 2018Article
- Microtome-integrated microscope system for high sensitivity tracking of in-resin fluorescence in blocks and ultrathin sections for correlative microscopy.Scientific reports · 2017Article
- The telomere bouquet facilitates meiotic prophase progression and exit in fission yeast.Cell discovery · 2017Article
- Mitotic Nuclear Envelope Breakdown and Spindle Nucleation Are Controlled by Interphase Contacts between Centromeres and the Nuclear Envelope.Developmental cell · 2016Article
- Differentiating the roles of microtubule-associated proteins at meiotic kinetochores during chromosome segregation.Chromosoma · 2016Review
- Chromosome domain architecture and dynamic organization of the fission yeast genome.FEBS letters · 2015Review
- Telomere protein Rap1 is a charge resistant scaffolding protein in chromosomal bouquet formation.BMC biology · 2015Article
- Meiotic nuclear movements in fission yeast are regulated by the transcription factor Mei4 downstream of a Cds1-dependent replication checkpoint pathway.Genes to cells : devoted to molecular & cellular mechanisms · 2015Article
- Gathering up meiotic telomeres: a novel function of the microtubule-organizing center.Cellular and molecular life sciences : CMLS · 2014Review
- The Chromosomal Courtship Dance-homolog pairing in early meiosis.Current opinion in cell biology · 2014Review
- Synchronized fission yeast meiosis using an ATP analog-sensitive Pat1 protein kinase.Nature protocols · 2014Article
- Mzt1/Tam4, a fission yeast MOZART1 homologue, is an essential component of the γ-tubulin complex and directly interacts with GCP3(Alp6).Molecular biology of the cell · 2013Article
- Microtubules and Alp7-Alp14 (TACC-TOG) reposition chromosomes before meiotic segregation.Nature cell biology · 2013Article
- Cuf2 boosts the transcription of APC/C activator Fzr1 to terminate the meiotic division cycle.EMBO reports · 2013Article
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12 authors at 6 institutions in 3 countries.
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Abstract
backgroundVigorous chromosome movements driven by cytoskeletal assemblies are a widely conserved feature of sexual differentiation to facilitate meiotic recombination. In fission yeast, this process involves the dramatic conversion of arrays of cytoplasmic microtubules (MTs), generated from multiple MT organizing centers (MTOCs), into a single radial MT (rMT) array associated with the spindle pole body (SPB), the major MTOC during meiotic prophase. The rMT is then dissolved upon the onset of meiosis I when a bipolar spindle emerges to conduct chromosome segregation. Structural features and molecular mechanisms that govern these dynamic MT rearrangements are poorly understood.
resultsElectron tomography of the SPBs showed that the rMT emanates from a newly recognized amorphous structure, which we term the rMTOC. The rMTOC, which resides at the cytoplasmic side of the SPB, is highly enriched in γ-tubulin reminiscent of the pericentriolar material of higher eukaryotic centrosomes. Formation of the rMTOC depends on Hrs1/Mcp6, a meiosis-specific SPB component that is located at the rMTOC. At the onset of meiosis I, Hrs1/Mcp6 is subject to strict downregulation by both proteasome-dependent degradation and phosphorylation leading to complete inactivation of the rMTOC. This ensures rMT dissolution and bipolar spindle formation.
conclusionsOur study reveals the molecular basis for the transient generation of a novel MTOC, which triggers a program of MT rearrangement that is required for meiotic differentiation.
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