ReviewTrends in endocrinology and metabolism: TEM2012
Epigenetics and diabetes treatment: an unrealized promise?
Review in Trends in endocrinology and metabolism: TEM, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed, 46 citations in OpenAlex.
- Review
- Sodium Butyrate, A Gut Microbiota Derived Metabolite in Type 2 Diabetes Mellitus and Cardiovascular Disease: A Review.Cardiovascular & hematological agents in medicinal chemistry · 2025Review
- SetD7 (Set7/9) is a novel target of PPARγ that promotes the adaptive pancreatic β-cell glycemic response.The Journal of biological chemistry · 2021Article
- Review
- Gene-diet quality interactions on haemoglobin A1c and type 2 diabetes risk: The Airwave Health Monitoring Study.Endocrinology, diabetes & metabolism · 2019Article
- The epigenetics of diabetes, obesity, overweight and cardiovascular disease.AIMS genetics · 2019Review
- Durable Control of Autoimmune Diabetes in Mice Achieved by Intraperitoneal Transplantation of "Neo-Islets," Three-Dimensional Aggregates of Allogeneic Islet and "Mesenchymal Stem Cells".Stem cells translational medicine · 2017Article
- Maternal butyrate supplementation induces insulin resistance associated with enhanced intramuscular fat deposition in the offspring.Oncotarget · 2017Article
- LIM domain-binding 1 maintains the terminally differentiated state of pancreatic β cells.The Journal of clinical investigation · 2017Article
- Epigenetic alterations in patients with type 2 diabetes mellitus.Balkan journal of medical genetics : BJMG · 2015Article
- Genomic-based tools for the risk assessment, management, and prevention of type 2 diabetes.The application of clinical genetics · 2015Review
- MicroRNAs with Specific Roles in Diabetes and Psychiatric Diseases.Clujul medical (1957) · 2014Review
- Detection of type 2 diabetes related modules and genes based on epigenetic networks.BMC systems biology · 2014Article
- Potential of epigenetic therapies in non-cancerous conditions.Frontiers in genetics · 2014Review
- Epigenetics and type II diabetes mellitus: underlying mechanisms of prenatal predisposition.Frontiers in cell and developmental biology · 2014Review
- The Missing lnc(RNA) between the pancreatic β-cell and diabetes.Frontiers in genetics · 2014Review
- Epigenetic effects of green tea polyphenols in cancer.Epigenomics · 2013Review
- Stem cells as a tool to improve outcomes of islet transplantation.Journal of transplantation · 2012Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Epigenetic mechanisms may contribute to the pathogenesis of complex diseases. Early or late environmental influences such as intrauterine malnutrition or sedentary lifestyle have been shown to lead to an increased risk of diabetes. Recently, epigenetic mechanisms were shown to be involved in endocrine cell differentiation and islet function. Genomic profiling of pancreatic islets in non-diabetic and diabetic states is needed in order to dissect the contribution of epigenetic mechanisms to the declining proliferation potential of β cells that we see with aging or the β-cell failure observed in diabetes. In-depth understanding of epigenetic landscapes can help to improve protocols for in vitro differentiation towards the β-cell fate, enhance β-cell proliferation, and lead to the discovery of novel therapeutic targets.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.