SynthesisThe Journal of allergy and clinical immunology2012
How should an incident case of atopic dermatitis be defined? A systematic review of primary prevention studies.
Synthesis in The Journal of allergy and clinical immunology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02906475 (A Randomized Pragmatic Parallel Group Trial to Investigate the Effectiveness of a Standardized Skin Care Regimen to Prevent the Development of Atopic Dermatitis in Atopy Predisposed Infants), which is not on this map. Cited by 23 papers, 4 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
A Randomized Pragmatic Parallel Group Trial to Investigate the Effectiveness of a Standardized Skin Care Regimen to Prevent the Development of Atopic Dermatitis in Atopy Predisposed Infants
Who cites it
23 citing papers in PubMed, 4 syntheses or guidelines pooled it, 61 citations in OpenAlex.
- Skin care interventions in infants for preventing eczema and food allergy.The Cochrane database of systematic reviews · 2022Pooled it
- What are the highest yielding search strategy terms for systematic reviews in atopic dermatitis? A systematic review.Archives of dermatological research · 2021Pooled it
- Skin care interventions in infants for preventing eczema and food allergy.The Cochrane database of systematic reviews · 2021Pooled it
- Neonatal Bacillus Calmette-Guérin Vaccination to Prevent Early-Life Eczema: A Systematic Review and Meta-analysis.Dermatitis : contact, atopic, occupational, drugPooled it
- Emollient application from birth to prevent eczema in high-risk children: the BEEP RCT.Health technology assessment (Winchester, England) · 2024Trial
- Daily emollient during infancy for prevention of eczema: the BEEP randomised controlled trial.Lancet (London, England) · 2020Trial
- Emollient enhancement of the skin barrier from birth offers effective atopic dermatitis prevention.The Journal of allergy and clinical immunology · 2014Trial
- Harmonizing epidemiological research methodology for atopic dermatitis research: protocol for the EPISTAR international consensus exercise.Skin health and disease · 2025Article
- Should Emollients Be Recommended for the Prevention of Atopic Dermatitis?-New Evidence and Current State of Knowledge.Journal of clinical medicine · 2024Review
- Identification of eczema clusters and their association with filaggrin and atopic comorbidities: analysis of five birth cohorts.The British journal of dermatology · 2023Article
- Reflectance Confocal Microscopy in Monitoring Atopic Dermatitis Treated with Topical Calcineurin Inhibitors.Healthcare (Basel, Switzerland) · 2023Article
- Prevention of Atopic Dermatitis.Acta dermato-venereologica · 2020Review
- Different definitions of atopic dermatitis: impact on prevalence estimates and associated risk factors.The British journal of dermatology · 2019Review
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- Article
- Incidence Trends of Atopic Dermatitis in Infancy and Early Childhood in a Nationwide Prescription Registry Study in Norway.JAMA network open · 2018Article
- The Long-Term Course of Atopic Dermatitis.Dermatologic clinics · 2017Review
- Prevention of allergies in childhood - where are we now?Allergologie select · 2017Review
- Deciphering the complexities of atopic dermatitis: shifting paradigms in treatment approaches.The Journal of allergy and clinical immunology · 2014Review
- Persistence of mild to moderate atopic dermatitis.JAMA dermatology · 2014Observational
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
Abstract
backgroundEczema prevention is now an active area of dermatologic and allergy research. Defining an incident case is therefore a prerequisite for such a study.
objectiveWe sought to examine how an incident case of atopic dermatitis was defined in previous atopic dermatitis prevention studies in order to make recommendations on a standard definition of new atopic dermatitis cases for use in future prevention trials.
methodsWe conducted a systematic review of controlled interventional atopic dermatitis prevention studies by using searches of MEDLINE and Cochrane databases for studies published from 1980 to the end of January 2011. Studies that included atopic dermatitis as a secondary outcome, such as asthma prevention trials, were included.
resultsOne hundred two studies were included in the final analysis, of which 27 (26.5%) did not describe any criteria for defining an incident case of atopic dermatitis. Of the remaining 75 studies with reported disease criteria, the Hanifin-Rajka criteria were the most commonly used (28 studies). A disease definition unique to that particular study (21 studies) was the second most commonly used disease definition, although the sources for such novel definitions were not cited.
conclusionsThe results from this systematic review highlight the need for improved reporting and standardization of the definition used for an incident case in atopic dermatitis prevention studies. Most prevention studies have used disease definitions such as the Hanifin-Rajka criteria that include disease chronicity. While acceptable for cumulative incidence outcomes, inclusion of disease chronicity precludes the precise measurement of disease onset. We propose a definition based on existing scientific studies that could be used in future prospective studies.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.