Evidence map›Paper›PMID 22424802›Full record

ReviewCurrent opinion in genetics & development2012

New and Xisting regulatory mechanisms of X chromosome inactivation.

Yesu Jeon, Kavitha Sarma, Jeannie T Lee

Abstract readReview
In one paragraph

Review in Current opinion in genetics & development, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 55 papers.

0numbers the graph read from it
0cells of the map it votes in
55citing papers in PubMed
10.3field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

55 citing papers in PubMed, 100 citations in OpenAlex.

  1. Review
  2. Review
  3. Article
  4. Review
  5. Article
  6. Epigenetic Reprogramming and Somatic Cell Nuclear Transfer.Methods in molecular biology (Clifton, N.J.) · 2023
    Review
  7. Review
  8. Review
  9. Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Review
  16. Article
  17. Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Yesu JeonHoward Hughes Medical Institute, Dept. of Molecular Biology, Massachusetts General Hospital, Dept. of Genetics, Harvard Medical School, Boston, MA 02114, USA.
Kavitha Sarma
Jeannie T Lee
Massachusetts General Hospital · US

Funding

Regulation of X-Inactivation by Non-Coding RNA LociR01GM058839 · NIGMS · MASSACHUSETTS GENERAL HOSPITAL · PI LEE, JEANNIE T · 1999 to 2025
$6.7M
Regulation of X-chromosome Inactivation and Imprinting by Non-coding ElementsR37GM058839 · NIGMS · MASSACHUSETTS GENERAL HOSPITAL · PI LEE, JEANNIE T · 2012 to 2021
$4.1M
Polycomb complexes targeted to specific loci by non-coding RNA co-factorsR01GM090278 · NIGMS · MASSACHUSETTS GENERAL HOSPITAL · PI LEE, JEANNIE T · 2010 to 2017
$3.7M
Deciphering the Role of MacroH2A in Non-coding RNA Mediated SilencingF32GM090765 · NIGMS · MASSACHUSETTS GENERAL HOSPITAL · PI SARMA, KAVITHA · 2010 to 2011
$99k
Howard Hughes Medical InstituteNIGMS NIH HHS F32 GM090765NIGMS NIH HHS F32-GM090765NIGMS NIH HHS R01 GM058839NIGMS NIH HHS R01 GM090278NIGMS NIH HHS R01-GM090278NIGMS NIH HHS R01-GM58839NIGMS NIH HHS R37 GM058839
6 · The paper itself

Abstract

Equalization of X linked gene expression is necessary in mammalian cells due to the presence of two X chromosomes in females and one in males. To achieve this, all female cells inactivate one of the two X chromosomes during development. This process, termed X chromosome inactivation (XCI), is a quintessential epigenetic phenomenon and involves a complex interplay between noncoding RNAs and protein factors. Progress in this area of study has consequently resulted in new approaches to study epigenetics and regulatory RNA function. Here we will discuss recent developments in the field that have advanced our understanding of XCI and its regulatory mechanisms.

Indexed as

X Chromosome InactivationAnimalsDNA DamageGene DosageGene Expression RegulationGene SilencingHumansRNA, UntranslatedRNA, Untranslated

Identifiers

PMID22424802
PMCPMC3361064
OpenAlexW1996781954

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.