ArticleClinical biomechanics (Bristol, Avon)2012
Symmetry of foot alignment and ankle flexibility in paediatric Charcot-Marie-Tooth disease.
Article in Clinical biomechanics (Bristol, Avon), 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
What it found
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Who cites it
7 citing papers in PubMed, 17 citations in OpenAlex.
- Asymmetric Cavovarus Deformity Presentation in Charcot-Marie-Tooth Disease.Foot & ankle orthopaedics · 2026Article
- Foot Assessment Clinical Scales in Charcot-Marie-Tooth Patients: A Scoping Review.Frontiers in human neuroscience · 2022Article
- How to manage pes cavus in children and adolescents?EFORT open reviews · 2021Review
- Innovative treatment for pes cavovarus: a pilot study of 13 children.Acta orthopaedica · 2018Article
- An observational study of asymmetry in CMT1A.Journal of neurology, neurosurgery, and psychiatry · 2015Observational
- Bilateral clubfeet are highly correlated: a cautionary tale for researchers.Clinical orthopaedics and related research · 2014Article
- Changes of gait pattern in children with Charcot-Marie-Tooth disease type 1A: a 18 months follow-up study.Journal of neuroengineering and rehabilitation · 2013Article
Corrections and comments
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Authors and funding
12 authors at 11 institutions in 4 countries.
Funding
Abstract
backgroundCharcot-Marie-Tooth disease is the most common inherited nerve disorder and typically presents with pes cavus foot deformity and ankle equinus during childhood. Level in the variation of symmetry of musculoskeletal lower limb involvement across the clinical population is unknown, despite early reports describing gross asymmetry.
methodsWe measured foot alignment and ankle flexibility of the left and right limbs using accurate and reliable standardised paediatric outcome measures in 172 patients aged 3-20 years with a variety of disease subtypes recruited from the United States, United Kingdom, Italy and Australia.
findingsWhile a large range of differences existed between left and right feet for a small proportion of children, there was no overall significant difference between limbs.
interpretationThere are two important implications of these findings. Children with Charcot-Marie-Tooth disease generally exhibit symmetrical foot alignment and ankle flexibility between limbs. As such, analysing one limb only for biomechanical-related research is appropriate and satisfies the independence requirements for statistical analysis. However, because there are large differences between feet for a small proportion of children, an individualised limb-focused approach to clinical care is required.
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