ReviewCurrent opinion in immunology2012
The role of CTCF in regulating V(D)J recombination.
Review in Current opinion in immunology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
30 citing papers in PubMed, 54 citations in OpenAlex.
- CRISPR-mediated precise large fragment insertion in zygotes enables rapid generation of humanized immunoglobulin heavy-chain mice.Immunity · 2026Article
- Elevated enhancer-oncogene contacts and higher oncogene expression levels by recurrent CTCF inactivating mutations in acute T cell leukemia.Cell reports · 2023Article
- Significant, replicable, and functional associations between KTN1 variants and alcohol and drug codependence.Addiction biology · 2021Article
- A Newly Assigned Role of CTCF in Cellular Response to Broken DNAs.Biomolecules · 2021Review
- KTN1 variants and risk for attention deficit hyperactivity disorder.American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics · 2020Article
- Genome organization in immune cells: unique challenges.Nature reviews. Immunology · 2019Review
- Long Noncoding RNACells · 2019Review
- Towards a map of cis-regulatory sequences in the human genome.Nucleic acids research · 2018Article
- Identification of the elementary structural units of the DNA damage response.Nature communications · 2017Article
- Defining the multivalent functions of CTCF from chromatin state and three-dimensional chromatin interactions.Nucleic acids research · 2016Article
- Expansion of epigenetic alterations in EFEMP1 promoter predicts malignant formation in pancreatobiliary intraductal papillary mucinous neoplasms.Journal of cancer research and clinical oncology · 2016Article
- A Damage-Independent Role for 53BP1 that Impacts Break Order and Igh Architecture during Class Switch Recombination.Cell reports · 2016Article
- Two Mutually Exclusive Local Chromatin States Drive Efficient V(D)J Recombination.Cell reports · 2016Article
- A uniform survey of allele-specific binding and expression over 1000-Genomes-Project individuals.Nature communications · 2016Article
- Methylation profile of bovineJournal of integrative agriculture : JIA · 2016Article
- Transient pairing of homologous Oct4 alleles accompanies the onset of embryonic stem cell differentiation.Cell stem cell · 2015Article
- CTCF-binding elements 1 and 2 in the Igh intergenic control region cooperatively regulate V(D)J recombination.Proceedings of the National Academy of Sciences of the United States of America · 2015Article
- Long-Range Regulation of V(D)J Recombination.Advances in immunology · 2015Review
- Genome-Wide Analyses Suggest Mechanisms Involving Early B-Cell Development in Canine IgA Deficiency.PloS one · 2015Article
- Article
Corrections and comments
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Authors and funding
2 authors at 2 institutions in 1 country.
Funding
Abstract
V(D)J recombination in B and T cells is required for the generation of receptors with a broad spectrum of specificity to foreign antigen. A total number of three immunoglobulin (Ig) and four T cell receptor (Tcr) loci can be targeted by the recombinase enzyme (RAG1/2) in a defined series of recombination events, which drive the progression of B and T cell development. This process is regulated at multiple levels to ensure lineage specific, ordered rearrangement and allelic exclusion. One key component of this is modulation of chromatin looping and locus contraction, which is important in bringing widely separated gene segments into close contact with each other to enable synapse formation for lineage and stage specific V gene rearrangement [2,3,4(•),5,6(•)]. Recent studies provide new insight into looping and its role in these processes. In this review we focus on the contribution of the 11 zinc finger nuclear protein, CTCF, in mediating loop formation and conformational changes that are important for the regulation of Ig and Tcr rearrangement.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.