Evidence map›Paper›PMID 22424460›Full record

ArticleJournal of medicinal food2012

Apple pomace, a by-product from the asturian cider industry, inhibits herpes simplex virus types 1 and 2 in vitro replication: study of its mechanisms of action.

Angel L Alvarez, Santiago Melón, Kevin P Dalton, Inés Nicieza, Annele Roque, Belén Suárez, Francisco Parra

Abstract read
In one paragraph

Article in Journal of medicinal food, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Angel L AlvarezAsturias Institute of Biotechnology, Department of Biochemistry and Molecular Biology, University of Oviedo, Oviedo, Spain. alvarezrangel@uniovi.es
Santiago Melón
Kevin P Dalton
Inés Nicieza
Annele Roque
Belén Suárez
Francisco Parra

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The anti-herpes simplex virus type 1 and anti-herpes simplex virus type 2 effects of apple pomace, a by-product from the cider-processing industry, were investigated. The mechanisms of antiviral action were assessed using a battery of experiments targeting sequential steps in the viral replication cycle. The anti-herpetic mechanisms of apple pomaces included the inhibition of virus attachment to the cell surface and the arrest of virus entry and uncoating. Quercitrin and procyanidin B2 were found to play a crucial role in the antiviral activity.

Indexed as

MalusAnimalsAntiviral AgentsFood IndustryFruitHerpes SimplexHerpesvirus 1, HumanHerpesvirus 2, HumanPhytotherapyPlant PreparationsVero CellsVirus ReplicationAntiviral AgentsPlant Preparations

Identifiers

PMID22424460
PMCPMC3359624

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.