ReviewThe Journal of nutritional biochemistry2012
Molecular mechanisms of chromium in alleviating insulin resistance.
Review in The Journal of nutritional biochemistry, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07711587 (A Pilot Study Investigating the Effects of Diaplex Supplementation on Glucose Regulation in Otherwise Healthy Adults With Elevated Blood Glucose Levels), which is not on this map. Cited by 76 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
A Pilot Study Investigating the Effects of Diaplex Supplementation on Glucose Regulation in Otherwise Healthy Adults With Elevated Blood Glucose Levels
Who cites it
76 citing papers in PubMed, 3 syntheses or guidelines pooled it, 239 citations in OpenAlex.
- Assessment of Serum Elements Concentration and Polycystic Ovary Syndrome (PCOS): Systematic Review and Meta-analysis.Biological trace element research · 2022Pooled it
- The Impact of Chromium Supplementation on Blood Pressure: A Systematic Review and Dose-Response Meta‑Analysis of Randomized‑Controlled Trials.High blood pressure & cardiovascular prevention : the official journal of the Italian Society of Hypertension · 2021Pooled it
- A Systematic Review of Dietary Supplements and Alternative Therapies for Weight Loss.Obesity (Silver Spring, Md.) · 2021Pooled it
- Trial
- Trivalent chromium versus baricitinib for rheumatoid arthritis treatment: first phase 2/3 randomized controlled trial, is trivalent chromium the upcoming immune-modulator?Inflammopharmacology · 2024Trial
- Controlling type-2 diabetes by inclusion of Cr-enriched yeast bread in the daily dietary pattern: a randomized clinical trial.European journal of nutrition · 2018Trial
- Assessment of Elemental Impurities and Associated Health Risks in Common Active Pharmaceutical Ingredients Using ICP-MS.Biological trace element research · 2026Article
- Chitosan-based nano-encapsulation enhances the anti-diabetic efficacy of Eremina desertorum extract by ameliorating hyperglycemia, oxidative stress, and inflammation in diabetic rats.Journal of materials science. Materials in medicine · 2026Article
- Tissue-Specific Accumulation and Dietary Risk of Arsenic and Other Potentially Toxic Elements in Retail Meats.Journal of xenobiotics · 2026Article
- Effects of Microminerals on Performance and Metabolic Adaptation in Heat-Stressed Dairy Cows: A Review.Biological trace element research · 2026Review
- Chromium as a Modulator of Insulin Receptor Activity: A Systematic Review of Its Role in Metabolic Syndrome and Type 2 Diabetes.Diabetes, metabolic syndrome and obesity : targets and therapy · 2026Review
- Impact of Dietary Supplemental Chromium and Zinc on the Performance of Laying Hens, Egg Quality, and Blood Chemistry.Scientifica · 2026Article
- Synthesis, Characterisation, and Biological Assessment of Chromium Oxide Nanoparticles Coated with Chia Seed Mucilage Extract.Pharmaceutics · 2025Article
- Consumption of Sericin Enhances the Bioavailability and Metabolic Efficacy of Chromium Picolinate in Rats.International journal of molecular sciences · 2025Article
- Protective effect of organic selenium and organic chromium dietary supplementation against aflatoxicosis in mice.Mycotoxin research · 2025Article
- Review
- Serum levels of trace elements in diabetic pregnant women and their relationship with growth indicators in newborns.Scientific reports · 2025Article
- Unravelling the developmental toxicity of heavy metals using zebrafish as a model: a narrative review.Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine · 2025Review
- Insights into the Age-Dependent Variation in Nutrition-Related Trace Elements in Diabetes Blood Using Total Reflection X-Ray Fluorescence.Biological trace element research · 2025Article
- Article
16 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Type 2 diabetes is often associated with obesity, dyslipidemia and cardiovascular anomalies and is a major health problem approaching global epidemic proportions. Insulin resistance, a prediabetic condition, precedes the onset of frank type 2 diabetes and offers potential avenues for early intervention to treat the disease. Although lifestyle modifications and exercise can reduce the incidence of diabetes, compliance has proved to be difficult, warranting pharmacological interventions. However, most of the currently available drugs that improve insulin sensitivity have adverse effects. Therefore, attractive strategies to alleviate insulin resistance include dietary supplements. One such supplement is chromium, which has been shown to reduce insulin resistance in some, but not all, studies. Furthermore, the molecular mechanisms of chromium in alleviating insulin resistance remain elusive. This review examines emerging reports on the effect of chromium, as well as molecular and cellular mechanisms by which chromium may provide beneficial effects in alleviating insulin resistance.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.