ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2012
In vivo nerve-macrophage interactions following peripheral nerve injury.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 77 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
77 citing papers in PubMed, 129 citations in OpenAlex.
- Article
- A glial cell-derived pathway directs regenerating optic nerve axons toward the optic chiasm.Development (Cambridge, England) · 2026Article
- A glial cell derived pathway directs regenerating optic nerve axons toward the optic chiasm.bioRxiv : the preprint server for biology · 2025Article
- Macrophage/microglia-dependent mechanisms drive retinal pigment epithelium regeneration in zebrafish.Cell reports · 2025Article
- Obesity negatively impacts corneal nerves in patients with diabetes mellitus.Eye and vision (London, England) · 2025Article
- Interleukin-34 and debris clearance by mononuclear phagocytes drive retinal pigment epithelium regeneration in zebrafish.bioRxiv : the preprint server for biology · 2025Article
- Advances in 3D printing combined with tissue engineering for nerve regeneration and repair.Journal of nanobiotechnology · 2025Review
- Modeling traumatic brain and neural injuries: insights from zebrafish.Frontiers in molecular neuroscience · 2025Review
- Cellular and molecular mechanisms of skin wound healing.Nature reviews. Molecular cell biology · 2024Review
- Impact of Obesity and Age on Mouse Corneal Innervation at the Epithelial-Stromal Interface.Investigative ophthalmology & visual science · 2024Article
- Target-selective vertebrate motor axon regeneration depends on interaction with glial cells at a peripheral nerve plexus.PLoS biology · 2023Article
- Zebrafish cutaneous injury models reveal that Langerhans cells engulf axonal debris in adult epidermis.Disease models & mechanisms · 2023Article
- A glia cell dependent mechanism at a peripheral nerve plexus critical for target-selective axon regeneration.bioRxiv : the preprint server for biology · 2023Article
- Live Imaging of Axonal Dynamics After Laser Axotomy of Peripheral Neurons in Zebrafish.Methods in molecular biology (Clifton, N.J.) · 2023Article
- Assaying Optic Nerve Regeneration in Larval Zebrafish.Methods in molecular biology (Clifton, N.J.) · 2023Article
- Article
- Wound Healing Insights from Flies and Fish.Cold Spring Harbor perspectives in biology · 2022Review
- Article
- The MAP3Ks DLK and LZK Direct Diverse Responses to Axon Damage in Zebrafish Peripheral Neurons.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2022Article
- The embryonic zebrafish brain is seeded by a lymphatic-dependent population of mrc1Nature neuroscience · 2022Article
17 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
In vertebrates, the peripheral nervous system has retained its regenerative capacity, enabling severed axons to reconnect with their original synaptic targets. While it is well documented that a favorable environment is critical for nerve regeneration, the complex cellular interactions between injured nerves with cells in their environment, as well as the functional significance of these interactions, have not been determined in vivo and in real time. Here we provide the first minute-by-minute account of cellular interactions between laser transected motor nerves and macrophages in live intact zebrafish. We show that macrophages arrive at the lesion site long before axon fragmentation, much earlier than previously thought. Moreover, we find that axon fragmentation triggers macrophage invasion into the nerve to engulf axonal debris, and that delaying nerve fragmentation in a Wld(s) model does not alter macrophage recruitment but induces a previously unknown 'nerve scanning' behavior, suggesting that macrophage recruitment and subsequent nerve invasion are controlled by separate mechanisms. Finally, we demonstrate that macrophage recruitment, thought to be dependent on Schwann cell-derived signals, occurs independently of Schwann cells. Thus, live cell imaging defines novel cellular and functional interactions between injured nerves and immune cells.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.