ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2012
Functional features of trans-differentiated hair cells mediated by Atoh1 reveals a primordial mechanism.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 34 citations in OpenAlex.
- Hearing restoration through hair cell regeneration: A review of recent advancements and current limitations.Hearing research · 2025Review
- Genetic and pharmacologic alterations of claudin9 levels suffice to induce functional and mature inner hair cells.bioRxiv : the preprint server for biology · 2024Article
- Sox9 Inhibits Cochlear Hair Cell Fate by Upregulating Hey1 and HeyL Antagonists of Atoh1.Cells · 2023Article
- Approaches to Treat Sensorineural Hearing Loss by Hair-Cell Regeneration: The Current State of Therapeutic Developments and Their Potential Impact on Audiological Clinical Practice.Journal of the American Academy of Audiology · 2021Article
- Developmental and Functional Hair Cell-Like Cells Induced by Atoh1 Overexpression in the Adult Mammalian CochleaNeural plasticity · 2020Article
- Article
- Evolutionary and Developmental Biology Provide Insights Into the Regeneration of Organ of Corti Hair Cells.Frontiers in cellular neuroscience · 2018Review
- Notch pathway inhibitor DAPT enhances Atoh1 activity to generate new hair cellsNeural regeneration research · 2017Article
- Cochlear hair cell regeneration after noise-induced hearing loss: Does regeneration follow development?Hearing research · 2017Review
- In Vivo Interplay between p27Cell reports · 2017Article
- Distinct capacity for differentiation to inner ear cell types by progenitor cells of the cochlea and vestibular organs.Development (Cambridge, England) · 2016Article
- Pseudo-immortalization of postnatal cochlear progenitor cells yields a scalable cell line capable of transcriptionally regulating mature hair cell genes.Scientific reports · 2015Article
- The Role of Atonal Factors in Mechanosensory Cell Specification and Function.Molecular neurobiology · 2015Article
- Characterization of the transcriptome of nascent hair cells and identification of direct targets of the Atoh1 transcription factor.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2015Article
- Atoh1 expression levels define the fate of rat cochlear nonsensory epithelial cells in vitro.Molecular medicine reports · 2014Article
- Hair cell regeneration after ATOH1 gene therapy in the cochlea of profoundly deaf adult guinea pigs.PloS one · 2014Article
- In vivo generation of immature inner hair cells in neonatal mouse cochleae by ectopic Atoh1 expression.PloS one · 2014Article
- Ectopic expression of activated notch or SOX2 reveals similar and unique roles in the development of the sensory cell progenitors in the mammalian inner ear.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2013Article
- Evolution and development of the tetrapod auditory system: an organ of Corti-centric perspective.Evolution & development · 2013Review
- Article
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Authors and funding
5 authors at 3 institutions in 2 countries.
Funding
Abstract
Evolution has transformed a simple ear with few vestibular maculae into a complex three-dimensional structure consisting of nine distinct endorgans. It is debatable whether the sensory epithelia underwent progressive segregation or emerged from distinct sensory patches. To address these uncertainties we examined the morphological and functional phenotype of trans-differentiated rat hair cells to reveal their primitive or endorgan-specific origins. Additionally, it is uncertain how Atoh1-mediated trans-differentiated hair cells trigger the processes that establish their neural ranking from the vestibulocochlear ganglia. We have demonstrated that the morphology and functional expression of ionic currents in trans-differentiated hair cells resemble those of "ancestral" hair cells, even at the lesser epithelia ridge aspects of the cochlea. The structures of stereociliary bundles of trans-differentiated hair cells were in keeping with cells in the vestibule. Functionally, the transient expression of Na⁺ and I(h) currents initiates and promotes evoked spikes. Additionally, Ca²⁺ current was expressed and underwent developmental changes. These events correlate well with the innervation of ectopic hair cells. New "born" hair cells at the abneural aspects of the cochlea are innervated by spiral ganglion neurons, presumably under the tropic influence of chemoattractants. The disappearance of inward currents coincides well with the attenuation of evoked electrical activity, remarkably recapitulating the development of hair cells. Ectopic hair cells underwent stepwise changes in the magnitude and kinetics of transducer currents. We propose that Atoh1 mediates trans-differentiation of morphological and functional "ancestral" hair cells that are likely to undergo diversification in an endorgan-specific manner.
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