ArticleBiology of reproduction2012
The Rhox5 homeobox gene regulates the region-specific expression of its paralogs in the rodent epididymis.
Article in Biology of reproduction, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 23 citations in OpenAlex.
- Conditional ablation of Insr and Igf1r using Esr2-Cre leads to abnormal ovarian follicle development and infertility in mice†.Biology of reproduction · 2025Article
- Rhox8 homeobox gene ablation leads to rete testis abnormality and male subfertility in mice†.Biology of reproduction · 2023Article
- Mammal Reproductive Homeobox (Rhox) Genes: An Update of Their Involvement in Reproduction and Development.Genes · 2023Review
- Review
- Article
- A novel transcriptional network for the androgen receptor in human epididymis epithelial cells.Molecular human reproduction · 2018Article
- Exposure to the widely used herbicide atrazine results in deregulation of global tissue-specific RNA transcription in the third generation and is associated with a global decrease of histone trimethylation in mice.Nucleic acids research · 2016Article
- Is the Epididymis a Series of Organs Placed Side By Side?Biology of reproduction · 2016Review
- Rhox8 Ablation in the Sertoli Cells Using a Tissue-Specific RNAi Approach Results in Impaired Male Fertility in Mice.Biology of reproduction · 2015Article
- Epigenetic regulation of the RHOX homeobox gene cluster and its association with human male infertility.Human molecular genetics · 2014Article
- The RHOX homeodomain proteins regulate the expression of insulin and other metabolic regulators in the testis.The Journal of biological chemistry · 2013Article
- Rhox in mammalian reproduction and development.Clinical and experimental reproductive medicine · 2013Review
- The RHOX homeobox gene cluster is selectively expressed in human oocytes and male germ cells.Human reproduction (Oxford, England) · 2013Article
- Female bias in Rhox6 and 9 regulation by the histone demethylase KDM6A.PLoS genetics · 2013Article
- Regulated expression of Rhox8 in the mouse ovary: evidence for the role of progesterone and RHOX5 in granulosa cells.Biology of reproduction · 2013Article
- The role of Rhox homeobox factors in tumorigenesis.Frontiers in bioscience (Landmark edition) · 2013Review
- DNA demethylation-dependent AR recruitment and GATA factors drive Rhox5 homeobox gene transcription in the epididymis.Molecular endocrinology (Baltimore, Md.) · 2012Article
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4 authors at 4 institutions in 1 country.
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Abstract
The mechanisms by which the region-specific expression patterns of clustered genes evolve are poorly understood. The epididymis is an ideal organ to examine this, as it is a highly segmented tissue that differs significantly in structure between closely related species. Here we examined this issue through analysis of the rapidly evolving X-linked reproductive homeobox (Rhox) gene cluster, the largest known homeobox gene cluster in metazoans. In the mouse, we found that most Rhox genes are expressed primarily in the caput region of the epididymis, a site where sperm mature and begin acquiring forward motility. This region-specific expression pattern depends, in part, on the founding member of the Rhox cluster--Rhox5--as targeted mutation of Rhox5 greatly diminishes the expression of several other family members in the caput region. In the rat, Rhox5 expression switches from the caput to the site of sperm storage: the cauda. All Rhox genes under the control of Rhox5 in the mouse epididymis display a concomitant change in their regional expression in the rat epididymis. Our results lead us to propose that widespread changes in the region-specific expression pattern of genes over evolutionary time can be the result of alterations of one or only a few master regulatory genes.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.