ArticleScience (New York, N.Y.)2012
Sexual deprivation increases ethanol intake in Drosophila.
Article in Science (New York, N.Y.), 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 111 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
111 citing papers in PubMed.
- Cellular source and circuit context organize functional specificity in thebioRxiv : the preprint server for biology · 2026Article
- Cell-type-resolved RNA-seq reveals molecular signatures of sexual experience inNAR genomics and bioinformatics · 2026Article
- Article
- Hugin-AstA circuitry is a novel central energy sensor that directly regulates sweet sensation ineLife · 2026Article
- Neuropeptide F-expressing neurons in Drosophila constitute centrifugal pathway to optic lobes.PloS one · 2026Article
- The exploration of consciousness in insects.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2025Review
- The social origins of consciousness.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2025Article
- Juvenile hormone regulates the maturation of sexually dimorphic naive ethanol olfactory preference inRoyal Society open science · 2025Article
- Article
- An olfactory model for evaluating the larviposition preference of a vector fly.Insect science · 2025Article
- Neuroecology of alcohol risk and reward: Methanol boosts pheromones and courtship success inScience advances · 2025Article
- The Molecular Basis of Love.International journal of molecular sciences · 2025Review
- Sex Differences in Mouse Models of Voluntary Alcohol Drinking and Abstinence-Induced Negative Emotion.Alcohol (Fayetteville, N.Y.) · 2024Review
- Mating reconciles fitness and fecundity by switching diet preference in flies.Nature communications · 2024Article
- Synaptic Mechanisms of Ethanol Tolerance and Neuroplasticity: Insights from Invertebrate Models.International journal of molecular sciences · 2024Review
- An integrative sensor of body states: how the mushroom body modulates behavior depending on physiological context.Learning & memory (Cold Spring Harbor, N.Y.) · 2024Review
- Review
- Transcriptomic comparison between populations selected for higher and lower mobility in the red flour beetle Tribolium castaneum.Scientific reports · 2024Article
- Article
- The neuropeptide drosulfakinin enhances choosiness and protects males from the aging effects of social perception.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
51 more citing papers are in PubMed but not listed here.
Corrections and comments
- Commented on by
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- Commented on by
- Erratum issuedMohammed, H [added]
- Erratum issued
Authors and funding
5 authors.
Funding
Abstract
The brain's reward systems reinforce behaviors required for species survival, including sex, food consumption, and social interaction. Drugs of abuse co-opt these neural pathways, which can lead to addiction. Here, we used Drosophila melanogaster to investigate the relationship between natural and drug rewards. In males, mating increased, whereas sexual deprivation reduced, neuropeptide F (NPF) levels. Activation or inhibition of the NPF system in turn reduced or enhanced ethanol preference. These results thus link sexual experience, NPF system activity, and ethanol consumption. Artificial activation of NPF neurons was in itself rewarding and precluded the ability of ethanol to act as a reward. We propose that activity of the NPF-NPF receptor axis represents the state of the fly reward system and modifies behavior accordingly.
Indexed as
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.