ArticleJournal of immunology (Baltimore, Md. : 1950)2012
CD27 stimulation promotes the frequency of IL-7 receptor-expressing memory precursors and prevents IL-12-mediated loss of CD8(+) T cell memory in the absence of CD4(+) T cell help.
Article in Journal of immunology (Baltimore, Md. : 1950), 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed, 45 citations in OpenAlex.
- Delivering co-stimulatory tumor necrosis factor receptor agonism for cancer immunotherapy: past, current and future perspectives.Frontiers in immunology · 2023Review
- Interrogating the CD27:CD70 axis in αCD40-dependent control of pancreatic adenocarcinoma.Frontiers in cell and developmental biology · 2023Article
- STAT3 Role in T-Cell Memory Formation.International journal of molecular sciences · 2022Review
- Memory T-Cell Heterogeneity and Terminology.Cold Spring Harbor perspectives in biology · 2021Review
- Effect of Sishen Pill on Memory T Cells From Experimental Colitis Induced by Dextran Sulfate Sodium.Frontiers in pharmacology · 2020Article
- Frontline Science: Late CD27 stimulation promotes IL-7Rα transcriptional re-expression and memory T cell qualities in effector CD8Journal of leukocyte biology · 2019Article
- CD27 Promotes CD4Journal of immunology (Baltimore, Md. : 1950) · 2019Article
- CD27-Mediated Regulatory T Cell Depletion and Effector T Cell Costimulation Both Contribute to Antitumor Efficacy.Journal of immunology (Baltimore, Md. : 1950) · 2017Article
- TNF-receptor superfamily agonists as molecular adjuvants for cancer vaccines.Current opinion in immunology · 2017Review
- Stimulating CD27 to quantitatively and qualitatively shape adaptive immunity to cancer.Current opinion in immunology · 2017Review
- NFκB-Pim-1-Eomesodermin axis is critical for maintaining CD8 T-cell memory quality.Proceedings of the National Academy of Sciences of the United States of America · 2017Article
- Acute Virus Control Mediated by Licensed NK Cells Sets Primary CD8+ T Cell Dependence on CD27 Costimulation.Journal of immunology (Baltimore, Md. : 1950) · 2016Article
- T Cell Vaccinology: Beyond the Reflection of Infectious Responses.Trends in immunology · 2016Review
- CD70 and IFN-1 selectively induce eomesodermin or T-bet and synergize to promote CD8+ T-cell responses.European journal of immunology · 2015Article
- Human Anti-CD40 Antibody and Poly IC:LC Adjuvant Combination Induces Potent T Cell Responses in the Lung of Nonhuman Primates.Journal of immunology (Baltimore, Md. : 1950) · 2015Article
- Distinct CD4 T-cell effects on primary versus recall CD8 T-cell responses during viral encephalomyelitis.Immunology · 2015Article
- IL-27 and the generation of CD8+ T-cell responses to peptide vaccines.Proceedings of the National Academy of Sciences of the United States of America · 2014Article
- IL-27 is required for shaping the magnitude, affinity distribution, and memory of T cells responding to subunit immunization.Proceedings of the National Academy of Sciences of the United States of America · 2014Article
- Regulation of tissue-dependent differences in CD8+ T cell apoptosis during viral infection.Journal of virology · 2014Article
- Accumulation of memory precursor CD8 T cells in regressing tumors following combination therapy with vaccine and anti-PD-1 antibody.Cancer research · 2014Article
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 3 countries.
Funding
Abstract
Fully functional CD8(+) T cell memory is highly dependent upon CD4(+) T cell support. CD4(+) T cells play a critical role in inducing the expression of CD70, the ligand for CD27, on dendritic cells. In this study, we demonstrate that CD27 stimulation during primary CD8(+) T cell responses regulates the ability to mount secondary CD8(+) T cell responses. CD27 stimulation during vaccinia and dendritic cell immunization controls the expression of the IL-7R (CD127), which has been shown to be necessary for memory CD8(+) T cell survival. Furthermore, CD27 stimulation during primary CD8(+) T cell responses to vaccinia virus restrained the late expression on memory precursor cells of cytokine receptors that support terminal differentiation. The formation of CD8(+) T cell memory precursors and secondary CD8(+) T cell responses was restored in the absence of CD27 costimulation when endogenous IL-12 was not available. Similarly, the lesion in CD8(+) T cell memory that occurs in the absence of CD4(+) T cells did not occur in mice lacking IL-12. These data indicate that CD4(+) T cell help and, by extension, CD27 stimulation support CD8(+) T cell memory by modulating the expression of cytokine receptors that influence the differentiation and survival of memory CD8(+) T cells.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.