ArticleJournal of applied physiology (Bethesda, Md. : 1985)2012
Hypoxia recruits intrapulmonary arteriovenous pathways in intact rats but not isolated rat lungs.
Article in Journal of applied physiology (Bethesda, Md. : 1985), 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
14 citing papers in PubMed, 24 citations in OpenAlex.
- Decreased arterial PO2, not O2 content, increases blood flow through intrapulmonary arteriovenous anastomoses at rest.The Journal of physiology · 2016Trial
- Effect of body position and oxygen tension on foramen ovale recruitment.American journal of physiology. Regulatory, integrative and comparative physiology · 2015Trial
- Hypoxia and exercise increase the transpulmonary passage of 99mTc-labeled albumin particles in humans.PloS one · 2014Trial
- Spontaneous peripheral oxygen desaturation and apnea events in mice vary by strain and inspired oxygen level.bioRxiv : the preprint server for biology · 2025Article
- Evaluation of intrapulmonary arteriovenous anastomoses before and after oxygen supplementation, using transthoracic agitated saline contrast echocardiography in rescued Korean raccoon dogs.Frontiers in veterinary science · 2024Article
- Hyperoxia-induced stepwise reduction in blood flow through intrapulmonary, but not intracardiac, shunt during exercise.American journal of physiology. Regulatory, integrative and comparative physiology · 2023Article
- Beta Adrenergic Regulation of Intrapulmonary Arteriovenous Anastomoses in Intact Rat and Isolated Rat Lungs.Frontiers in physiology · 2017Article
- Imaging technologies for monitoring the safety, efficacy and mechanisms of action of cell-based regenerative medicine therapies in models of kidney disease.European journal of pharmacology · 2016Review
- Arterio-venous anastomoses in isolated, perfused rat lungs.Physiological reports · 2016Article
- Intrapulmonary arteriovenous anastomoses in humans--response to exercise and the environment.The Journal of physiology · 2015Review
- Increased cardiac output, not pulmonary artery systolic pressure, increases intrapulmonary shunt in healthy humans breathing room air and 40% O2.The Journal of physiology · 2014Article
- Ultrasound assessment of ex vivo lung tissue properties using a fluid-filled negative pressure bath.Journal of biomechanical engineering · 2014Article
- Transient intrapulmonary shunting in a patient treated with β₂-adrenergic agonists for status asthmaticus.Pediatrics · 2014Article
- Overbuilt for exercise or not: how do lung structure and distensibility impact exercise capacity?The Journal of physiology · 2013Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
Abstract
Intrapulmonary arteriovenous anastomoses (IPAVS) directly connect the arterial and venous circulations in the lung, bypassing the capillary network. Here, we used solid, latex microspheres and isolated rat lung and intact, spontaneously breathing rat models to test the hypothesis that IPAVS are recruited by alveolar hypoxia. We found that hypoxia recruits IPAVS in the intact rat, but not the isolated lung. IPAVS are at least 70 μm in the rat and, interestingly, appear to be recruited when the mixed venous Po(2) falls below 22 mmHg. These data provide evidence that large-diameter, direct arteriovenous connections exist in the lung and are recruitable by hypoxia in the intact animal.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.