ArticleJournal of applied physiology (Bethesda, Md. : 1985)2012
Effect of hyperoxic exposure during early development on neurotrophin expression in the carotid body and nucleus tractus solitarii.
Article in Journal of applied physiology (Bethesda, Md. : 1985), 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
19 citing papers in PubMed, 28 citations in OpenAlex.
- Effect of Intermittent Hypoxemia and Hyperoxemia during the Neonatal Period on Control of Breathing Function among Infants Born Extremely Preterm.The Journal of pediatrics · 2025Observational
- Contributions of carotid bodies, retrotrapezoid nucleus neurons and preBötzinger complex astrocytes to the COThe Journal of physiology · 2024Article
- K252a Prevents Microglial Activation Induced by Anoxic Stimulation of Carotid Bodies in Rats.Toxics · 2023Article
- Neurochemical Plasticity of the Carotid Body.Advances in anatomy, embryology, and cell biology · 2023Article
- An open-source tool for automated analysis of breathing behaviors in common marmosets and rodents.eLife · 2022Article
- Article
- Growth Factors in the Carotid Body-An Update.International journal of molecular sciences · 2020Review
- Blood and urine biomarkers associated with long-term respiratory dysfunction following neonatal hyperoxia exposure: Implications for prematurity and risk of SIDS.Respiratory physiology & neurobiology · 2020Article
- Mechanistic actions of oxygen and methylxanthines on respiratory neural control and for the treatment of neonatal apnea.Respiratory physiology & neurobiology · 2020Review
- Combined effects of intermittent hyperoxia and intermittent hypercapnic hypoxia on respiratory control in neonatal rats.Respiratory physiology & neurobiology · 2019Article
- Ventilatory and chemoreceptor responses to hypercapnia in neonatal rats chronically exposed to moderate hyperoxia.Respiratory physiology & neurobiology · 2017Article
- Chronic intermittent hyperoxia alters the development of the hypoxic ventilatory response in neonatal rats.Respiratory physiology & neurobiology · 2016Article
- Role of TrkB during the postnatal development of the rat carotid body.Respiratory physiology & neurobiology · 2015Article
- Postnatal development of eupneic ventilation and metabolism in rats chronically exposed to moderate hyperoxia.Respiratory physiology & neurobiology · 2014Article
- Perinatal hyperoxic exposure reconfigures the central respiratory network contributing to intolerance to anoxia in newborn rat pups.Journal of applied physiology (Bethesda, Md. : 1985) · 2014Article
- Proposed toxic and hypoxic impairment of a brainstem locus in autism.International journal of environmental research and public health · 2013Article
- Ventilatory control in infants, children, and adults with bronchopulmonary dysplasia.Respiratory physiology & neurobiology · 2013Review
- Peripheral-central chemoreceptor interaction and the significance of a critical period in the development of respiratory control.Respiratory physiology & neurobiology · 2013Review
- Chronic hyperoxia and the development of the carotid body.Respiratory physiology & neurobiology · 2013Review
Corrections and comments
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Authors and funding
8 authors at 4 institutions in 2 countries.
Funding
Abstract
Synaptic activity can modify expression of neurotrophins, which influence the development of neuronal circuits. In the newborn rat, early hyperoxia silences the synaptic activity and input from the carotid body, impairing the development and function of chemoreceptors. The purpose of this study was to determine whether early hyperoxic exposure, sufficient to induce hypoplasia of the carotid body and decrease the number of chemoafferents, would also modify neurotrophin expression within the nucleus tractus solitarii (nTS). Rat pups were exposed to hyperoxia (fraction of inspired oxygen 0.60) or normoxia until 7 or 14 days of postnatal development (PND). In the carotid body, hyperoxia decreased brain-derived neurotrophic factor (BDNF) protein expression by 93% (P = 0.04) after a 7-day exposure, followed by a decrease in retrogradely labeled chemoafferents by 55% (P = 0.004) within the petrosal ganglion at 14 days. Return to normoxia for 1 wk after a 14-day hyperoxic exposure did not reverse this effect. In the nTS, hyperoxia for 7 days: 1) decreased BDNF gene expression by 67% and protein expression by 18%; 2) attenuated upregulation of BDNF mRNA levels in response to acute hypoxia; and 3) upregulated p75 neurotrophic receptor, truncated tropomyosin kinase B (inactive receptor), and cleaved caspase-3. These effects were not observed in the locus coeruleus (LC). Hyperoxia for 14 days also decreased tyrosine hydroxylase levels by 18% (P = 0.04) in nTS but not in the LC. In conclusion, hyperoxic exposure during early PND reduces neurotrophin levels in the carotid body and the nTS and shifts the balance of neurotrophic support from prosurvival to proapoptotic in the nTS, the primary brain stem site for central integration of sensory and autonomic inputs.
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