Evidence map›Paper›PMID 22422445›Full record

SynthesisClinical research in cardiology : official journal of the German Cardiac Society2012

Everolimus-eluting versus sirolimus-eluting stents: an updated meta-analysis of randomized trials.

Antoinette de Waha, Salvatore Cassese, Duk-Woo Park, Francesco Burzotta, Robert A Byrne, Tomohisa Tada, Lamin A King, Seung-Jung Park, Albert Schömig, Adnan Kastrati

Abstract readComparative StudyMeta-Analysis
PubMed Publisher
In one paragraph

Synthesis in Clinical research in cardiology : official journal of the German Cardiac Society, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed, 5 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 5 syntheses or guidelines pooled it.

  1. Prolonged dual antiplatelet therapy after drug-eluting stenting: meta-analysis of randomized trials.Clinical research in cardiology : official journal of the German Cardiac Society · 2015
    Pooled it
  2. Investigating the role of acute mental stress on endothelial dysfunction: a systematic review and meta-analysis.Clinical research in cardiology : official journal of the German Cardiac Society · 2015
    Pooled it
  3. Pooled it
  4. Drug-eluting stents in patients with anterior STEMI undergoing primary angioplasty: a substudy of the DESERT cooperation.Clinical research in cardiology : official journal of the German Cardiac Society · 2014
    Pooled it
  5. Pooled it
  6. Trial
  7. Article
  8. Article
  9. Cardiac surgery 2014 reviewed.Clinical research in cardiology : official journal of the German Cardiac Society · 2015
    Review
  10. Article
  11. Saphenous vein graft interventions.Current treatment options in cardiovascular medicine · 2014 · on this map
    Article
  12. Use of drug-eluting stents in acute myocardial infarction with persistent ST-segment elevation: results of the ALKK PCI-registry.Clinical research in cardiology : official journal of the German Cardiac Society · 2014
    Article
  13. Article
  14. Observational
  15. Article
  16. Assessment of an asymmetrical coating stent with sirolimus released from ablumial matrix in porcine model.Clinical research in cardiology : official journal of the German Cardiac Society · 2012
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Antoinette de WahaDeutsches Herzzentrum and 1. Med. Klinik, Klinikum rechts der Isar, Technische Universität, Lazarettstr. 36, 80636 Munich, Germany. dewaha@dhm.mhn.de
Salvatore Cassese
Duk-Woo Park
Francesco Burzotta
Robert A Byrne
Tomohisa Tada
Lamin A King
Seung-Jung Park
Albert Schömig
Adnan Kastrati

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundEverolimus-eluting stents (EES; Xience V) are among the most commonly used newer generation drug-eluting stents in clinical practice and have clearly proven superiority over paclitaxel-eluting stents. Nevertheless, the relative merits of EES against the previous gold-standard sirolimus-eluting stent (SES; Cypher) have been less extensively assessed. We aimed to compare the clinical outcomes of EES with SES in patients with coronary artery disease undergoing percutaneous coronary intervention. METHODS AND

resultsWe identified eight eligible randomized trials comparing EES with SES including 11,167 patients. The primary endpoint was the incidence of major adverse cardiac events (MACE). Secondary endpoints were target lesion revascularization (TLR) and the composite of definite and probable stent thrombosis. The follow-up ranged from 9 to 36 months. No heterogeneity across the trials was observed regarding the selected endpoints. There was no difference in risk of MACE (HR 0.91 [0.79-1.04]; p = 0.15), TLR (HR 0.86 [0.72-1.04]; p = 0.12) and the composite of definite and probable stent thrombosis (HR 0.84 [0.54-1.29], p = 0.42). The risk of definite stent thrombosis was significantly lower in patients receiving EES (HR 0.49 [0.27 to 0.91]; p = 0.02).

conclusionUsing the largest available dataset of patients treated in randomized trials, the present meta-analysis demonstrated that the use of EES versus SES was associated with comparable incidence of overall clinical events. However, EES may be associated with a lower risk of definite stent thrombosis.

Indexed as

Drug-Eluting StentsCoronary Artery DiseaseEverolimusHumansRandomized Controlled Trials as TopicSirolimusThrombosisTime FactorsTreatment OutcomeEverolimusSirolimus

Identifiers

PMID22422445

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.