SynthesisInternational urogynecology journal2012
A systematic review of clinical studies on hereditary factors in pelvic organ prolapse.
Synthesis in International urogynecology journal, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers, 6 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
39 citing papers in PubMed, 6 syntheses or guidelines pooled it, 106 citations in OpenAlex.
- The prevalence of pelvic organ prolapse and associated factors in Ethiopia: a systematic review and meta-analysis.Frontiers in medicine · 2023Pooled it
- Systematic review and meta-analysis of genetic association studies of pelvic organ prolapse.International urogynecology journal · 2022Pooled it
- Family history and pelvic organ prolapse: a systematic review and meta-analysis.International urogynecology journal · 2021Pooled it
- Pooled it
- Genome-wide association identifies seven loci for pelvic organ prolapse in Iceland and the UK Biobank.Communications biology · 2020Pooled it
- Systematic review and metaanalysis of genetic association studies of urinary symptoms and prolapse in women.American journal of obstetrics and gynecology · 2015Pooled it
- Non-Titanised Compared to Titanised Polypropylene Meshes Induce a Pro-Inflammatory and Anti-Angiogenic Response in Fibroblast Co-Cultures.Cell biochemistry and biophysics · 2026Article
- Molecular Alterations in Vaginal Wall Tissues Associated with Post-Hysterectomy Pelvic Organ Prolapse.Current medical science · 2026Article
- Factors Associated With Self-reported Family History of Pelvic Floor Disorders.Urogynecology (Philadelphia, Pa.) · 2026Article
- Laparoscopic pectopexy for the treatment of pelvic organ prolapse (POP): how, why, when: a narrative review of the literature.Facts, views & vision in ObGyn · 2025Article
- Review
- Fortifying the foundation: assessing the role of uterine ligament integrity in uterine prolapse and beyond.Archives of gynecology and obstetrics · 2024Review
- Anterior pelvic organ prolapse repair: the intersection of science and art.Gynecology and pelvic medicine · 2024Article
- Molecular Landscape of Pelvic Organ Prolapse Provides Insights into Disease Etiology.International journal of molecular sciences · 2023Article
- Characteristics and outcomes of patients with pelvic organ prolapse: an analysis of data from Mulago National Referral Hospital from 2007-2016.African health sciences · 2023Article
- Urogynecology in obstetrics: impact of pregnancy and delivery on pelvic floor disorders, a prospective longitudinal observational pilot study.Archives of gynecology and obstetrics · 2021Observational
- Genome-Wide Association Study of Pelvic Organ Prolapse Using the Michigan Genomics Initiative.Female pelvic medicine & reconstructive surgery · 2021Article
- Collagen type 1A1, type 3A1, and LOXL1/4 polymorphisms as risk factors of pelvic organ prolapse.BMC research notes · 2021Article
- Collagen type 3A1 and 1A1 polymorphisms in women with pelvic organ prolapse and urinary incontinence assessed with Sanger sequencing method.Central European journal of urology · 2021Article
- Identification of pelvic organ prolapse risk susceptibility gene SNP locus in Xinjiang women.International urogynecology journal · 2020Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introduction and hypothesisThere is growing evidence that pelvic organ prolapse (POP) is at least partly caused by underlying hereditary risk factors. The aim of our study was to provide a systematic literature review and meta-analysis of clinical studies on family history of POP as a risk factor for POP in individual women.
methodsThe databases PubMed and Embase were searched. Clinical studies reporting on family history of POP in relation to POP in individual women were included.
resultsSixteen studies were included, of which eight enabled us to calculate a pooled odds ratio (OR). The pooled OR of POP in case of a positive family history of POP was 2.58 (95 % confidence interval 2.12-3.15).
conclusionsWomen with POP are substantially more likely to have family members with the same condition compared to women without POP. This strengthens the hypothesis that genetic predisposition plays an important role in the development of POP.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.