Trial reportWorld journal of surgery2012
Combining early postoperative parathyroid hormone and serum calcium levels allows for an efficacious selective post-thyroidectomy supplementation treatment.
Trial report in World journal of surgery, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 2 of them syntheses that pooled it.
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Who cites it
18 citing papers in PubMed, 2 syntheses or guidelines pooled it, 60 citations in OpenAlex.
- Pooled it
- Definition and diagnosis of postsurgical hypoparathyroidism after thyroid surgery: meta-analysis.BJS open · 2022Pooled it
- Early prediction of hypocalcemia following thyroid surgery. A prospective randomized clinical trial.Langenbeck's archives of surgery · 2017Trial
- Mini-invasive video-assisted thyroidectomy vs robot-assisted transaxillary thryoidectomy: analisys and comparison of safety and outcomes.Updates in surgery · 2024Observational
- Management of surgical diseases of thyroid gland indications of the United Italian Society of Endocrine Surgery (SIUEC).Updates in surgery · 2023Article
- The role of early postoperative parathyroid hormone level after total thyroidectomy in prediction of hypocalcemia.Annals of medicine and surgery (2012) · 2021Article
- Correlation between iPTH Levels on the First Postoperative Day After Total Thyroidectomy and Permanent Hypoparathyroidism: Our Experience.Open medicine (Warsaw, Poland) · 2019Article
- Hypocalcemia after thyroidectomy: iPTH levels and iPTH decline are predictive? Retrospective cohort study.Annals of medicine and surgery (2012) · 2018Article
- Modification, validation and implementation of a protocol for post-thyroidectomy hypocalcaemia.Annals of the Royal College of Surgeons of England · 2018Article
- Video-Assisted Thyroidectomy for Papillary Thyroid Carcinoma: Oncologic Outcome in Patients with Follow-Up ≥ 10 Years.World journal of surgery · 2018Article
- Parathyroid Hormone Assays following Total Thyroidectomy: Is There a Predictive Value?European thyroid journal · 2018Article
- How to avoid and to manage post-operative complications in thyroid surgery.Updates in surgery · 2017Review
- Diagnostic, therapeutic and health-care management protocol in thyroid surgery: a position statement of the Italian Association of Endocrine Surgery Units (U.E.C. CLUB).Journal of endocrinological investigation · 2016Article
- Necessity of therapy for post-thyroidectomy hypocalcaemia: a multi-centre experience.Langenbeck's archives of surgery · 2015Observational
- [Avoidance and management of hypoparathyroidism after thyroid gland surgery].Der Chirurg; Zeitschrift fur alle Gebiete der operativen Medizen · 2015Review
- Morbidity of central neck dissection: primary surgery vs reoperation. Results of a case-control study.Langenbeck's archives of surgery · 2014Article
- How useful are perioperative biochemical parameters in predicting the duration of calcium and/or vitamin D supplementation after total thyroidectomy?World journal of surgery · 2013Article
- WHAT SHOULD BE THE APPROACH TO MODERATE HYPOCALCAEMIA IN THE EARLY PERIOD FOLLOWING TOTAL THYROIDECTOMY?Acta endocrinologica (Bucharest, Romania : 2005)Article
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundOptimal treatment protocol to prevent symptomatic hypocalcemia following total thyroidectomy is still matter of debate. We prospectively evaluated the efficacy of a selective supplementation protocol based on both early postoperative intact parathyroid hormone (iPTH) and serum calcium levels.
methodsTwo hundred thirty consecutive patients were divided in three different groups of treatment according to iPTH levels 4 h after total thyroidectomy (4 h-iPTH) and serum calcium levels in the first postoperative day (1PO-Ca): group A (4 h-iPTH > 10 pg/ml, 1PO-Ca ≥ 8.5 mg/dl), no treatment; group B (4 h-iPTH > 10 pg/ml, 1PO-Ca < 8.5 mg/dl), oral calcium (OC) 3 g per day; and group C (4 h-iPTH ≤ 10 pg/ml), OC 3 g + calcitriol (VD) 1 μg per day. Development of biochemical and/or symptomatic hypocalcemia was evaluated.
resultsFifty-nine patients (25.6%) had subnormal 4 h-iPTH levels (≤10 pg/ml) (group C). Among patients with normal 4 h-iPTH levels, 25 (10.9%) had subnormal 1PO-Ca (<8.5 mg/dl) (group B). The remaining 146 patients (63.5%) had normal 4 h-iPTH and 1PO-Ca levels (group A). One patient in group A, 2 in group B, and 18 in group C developed biochemical hypocalcemia. Only one patient in group C experienced major symptoms. Treatment was discontinued within 1 month in all the patients in group B. At a mean follow-up of 303 days, five patients in group C were still under supplementation treatment.
conclusionThe proposed supplementation protocol seems efficacious in preventing symptomatic hypocalcemia. It could allow a safe and early discharge of most patients, thus avoiding the constraints and the costs of routine supplementation.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.