Evidence map›Paper›PMID 22422066›Full record

ArticleThe Journal of general virology2012

A third gyrovirus species in human faeces.

Tung G Phan, Linlin Li, Miguel G O'Ryan, Hector Cortes, Nora Mamani, Isidore J O Bonkoungou, Chunling Wang, Christian M Leutenegger, Eric Delwart

Open access · greenAbstract read
In one paragraph

Article in The Journal of general virology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 50 papers.

0numbers the graph read from it
0cells of the map it votes in
50citing papers in PubMed
15.2field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

50 citing papers in PubMed, 84 citations in OpenAlex.

  1. Article
  2. Molecular Characterization of EmergingInternational journal of molecular sciences · 2026
    Article
  3. Article
  4. Article
  5. Review
  6. Article
  7. Gyrovirus: current status and challenge.Frontiers in microbiology · 2024
    Review
  8. Article
  9. Article
  10. Article
  11. Review
  12. Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. Genetic Analysis of Avian Gyrovirus 2 Variant-RelatedPathogens (Basel, Switzerland) · 2019
    Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 5 institutions in 3 countries.

Tung G PhanDepartment of Laboratory Medicine, University of California at San Francisco, San Francisco, CA 94118, USA.
Linlin LiDepartment of Laboratory Medicine, University of California at San Francisco, San Francisco, CA 94118, USA.
Miguel G O'RyanInstitute of Biomedical Sciences, Faculty of Medicine, University of Chile, Santiago, Chile.
Hector CortesInstitute of Biomedical Sciences, Faculty of Medicine, University of Chile, Santiago, Chile.
Nora MamaniInstitute of Biomedical Sciences, Faculty of Medicine, University of Chile, Santiago, Chile.
Isidore J O BonkoungouLaboratoire National de Santé Publique, 09 BP 24, Ouagadougou, Burkina Faso.
Chunling WangDivision of Infectious Diseases, Stanford University Medical Center, Stanford, CA 94305, USA.
Christian M LeuteneggerIDEXX Reference Laboratories, West Sacramento, CA 95605, USA.
Eric DelwartDepartment of Laboratory Medicine, University of California at San Francisco, San Francisco, CA 94118, USA.
University of Chile · CLBlood Systems Research Institute · USIDEXX Laboratories (France) · FRStanford University · USUniversity of California, San Francisco · US

Funding

Metagenomic detection of emerging viruses in the blood supplyR01HL105770 · NHLBI · VITALANT · PI DELWART, ERIC L · 2011 to 2015
$2.4M
Metagenomic analysis of the human viromeR01HL083254 · NHLBI · VITALANT · PI DELWART, ERIC L · 2007 to 2010
$1.6M
NHLBI NIH HHS R01 HL083254NHLBI NIH HHS R01HL083254NHLBI NIH HHS R01 HL105770
6 · The paper itself

Abstract

Until 2011 the genus Gyrovirus in the family Circoviridae consisted of a single virus (Chicken anemia virus or CAV) causing a common immunosuppressive disease in chickens when a second gyrovirus (HGyV) was reported on the skin of 4 % of healthy humans. HGyV is very closely related to a recently described chicken gyrovirus, AGV2, suggesting that they belong to the same viral species. During a viral metagenomic analysis of 100 human faeces from children with diarrhoea in Chile we identified multiple known human pathogens (adenoviruses, enteroviruses, astroviruses, sapoviruses, noroviruses, parechoviruses and rotaviruses) and a novel gyrovirus species we named GyV3 sharing <63 % similarity with other gyrovirus proteins with evidence of recombination with CAV in its UTR. Gyroviridae consensus PCR revealed a high prevalence of CAV DNA in diarrhoea and normal faeces from Chilean children and faeces of USA cats and dogs, which may reflect consumption of CAV-infected/vaccinated chickens. Whether GyV3 can infect humans and/or chickens requires further studies.

Indexed as

AnimalsCatsChickensChildChileCircoviridae InfectionsDogsFecesFood ContaminationGyrovirusHumansMolecular Sequence DataPoultry Diseases

Identifiers

PMID22422066
PMCPMC3755516
OpenAlexW2115546603

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.