Evidence map›Paper›PMID 22421734›Full record

Trial reportPhysical therapy2012

Neuromuscular electrical stimulation for intensive care unit-acquired weakness: protocol and methodological implications for a randomized, sham-controlled, phase II trial.

Michelle E Kho, Alexander D Truong, Roy G Brower, Jeffrey B Palmer, Eddy Fan, Jennifer M Zanni, Nancy D Ciesla, Dorianne R Feldman, Radha Korupolu, Dale M Needham

Registry-linked trialOpen access · bronzeAbstract readClinical Trial, Phase IIRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Physical therapy, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02706587 (Neuromuscular Electrical Stimulation for Intensive Care Unit-acquired Weakness), which is not on this map. Cited by 11 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed, 3 pooled it
3.7field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02706587 phase3unknown statusnot on this mapstarted 2016, after this paper: background citation

Neuromuscular Electrical Stimulation for Intensive Care Unit-acquired Weakness

TypeinterventionalSponsorInstitut Mutualiste MontsourisRan2016 to 2018Enrolled102ConditionsPolyneuropathy, Critical IllnessArmsNeuromuscular electrical stimulation, Sham control
3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 3 syntheses or guidelines pooled it, 39 citations in OpenAlex.

  1. Physical rehabilitation for critical illness myopathy and neuropathy.The Cochrane database of systematic reviews · 2015
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 2 countries.

Michelle E KhoDepartment of Physical Medicine and Rehabilitation, Johns Hopkins University, Phipps 197, 600 N Wolfe St, Baltimore, MD 21287, USA.
Alexander D Truong
Roy G Brower
Jeffrey B Palmer
Eddy Fan
Jennifer M Zanni
Nancy D Ciesla
Dorianne R Feldman
Radha Korupolu
Dale M Needham
Johns Hopkins University · USEmory University · USUniversity of Kentucky · USUniversity of Toronto · CA

Funding

Institute for Clinical and Translational Research (UL1)UL1RR025005 · NCRR · JOHNS HOPKINS UNIVERSITY · PI FORD, DANIEL ERNEST · 2007 to 2011
$75.8M
NCRR NIH HHS UL1 RR 025005NCRR NIH HHS UL1 RR025005
6 · The paper itself

Abstract

backgroundAs the population ages and critical care advances, a growing number of survivors of critical illness will be at risk for intensive care unit (ICU)-acquired weakness. Bed rest, which is common in the ICU, causes adverse effects, including muscle weakness. Consequently, patients need ICU-based interventions focused on the muscular system. Although emerging evidence supports the benefits of early rehabilitation during mechanical ventilation, additional therapies may be beneficial. Neuromuscular electrical stimulation (NMES), which can provide some muscular activity even very early during critical illness, is a promising modality for patients in the ICU.

objectiveThe objectives of this article are to discuss the implications of bed rest for patients with critical illness, summarize recent studies of early rehabilitation and NMES in the ICU, and describe a protocol for a randomized, phase II pilot study of NMES in patients receiving mechanical ventilation.

designThe study was a randomized, sham-controlled, concealed, phase II pilot study with caregivers and outcome assessors blinded to the treatment allocation.

settingThe study setting will be a medical ICU.

participantsThe study participants will be patients who are receiving mechanical ventilation for 1 day or more, who are expected to stay in the ICU for an additional 2 days or more, and who meet no exclusion criteria.

interventionThe intervention will be NMES (versus a sham [control] intervention) applied to the quadriceps, tibialis anterior, and gastrocnemius muscles for 60 minutes per day. MEASUREMENTS: Lower-extremity muscle strength at hospital discharge will be the primary outcome measure. LIMITATIONS: Muscle strength is a surrogate measure, not a patient-centered outcome. The assessments will not include laboratory, genetic, or histological measures aimed at a mechanistic understanding of NMES. The optimal duration or dose of NMES is unclear.

conclusionsIf NMES is beneficial, the results of the study will help advance research aimed at reducing the burden of muscular weakness and physical disability in survivors of critical illness.

Indexed as

Electric Stimulation TherapyIntensive Care UnitsBed RestCritical IllnessHumansLower ExtremityMuscle StrengthMuscle Strength DynamometerMuscle WeaknessPilot ProjectsResearch Design

Identifiers

PMID22421734
PMCPMC3513483
OpenAlexW2169318458

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.