ReviewNature reviews. Genetics2012
Endogenous viruses: insights into viral evolution and impact on host biology.
Review in Nature reviews. Genetics, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 385 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
385 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Human endogenous retroviruses as immune-related prognostic biomarkers in pancreatic cancer.BMC cancer · 2026Pooled it
- Disrupting Mechanisms that Regulate Genomic Repeat Elements to Combat Cancer and Drug Resistance.Frontiers in cell and developmental biology · 2022Pooled it
- Endogenous RNA virus-derived elements exhibit functional divergence in modulating development and virus susceptibility inVirulence · 2026Article
- Multiple Sclerosis and Viruses: « Liaisons Dangereuses ».Reviews in medical virology · 2026Review
- Endogenous retrovirus control of calbindin is essential for human early embryogenesis.Science advances · 2026Article
- Virome Diversity in Three Bat Species in Different Environments in Southern Spain.Microorganisms · 2026Article
- Identification of Partitivirus-like RdRPs in theViruses · 2026Article
- Evaluating the Effect of Sampling Scale on Mosquito Virome Characterization Using PacBio HiFi Long-Read Metagenomics.Insects · 2026Article
- Beyond Genetic Conservation: The Baton Pass Model of Essential Biological Functions.Biomolecules · 2026Review
- Article
- Identification and characterization of an endogenous pararetrovirus in Gentiana triflora plants.Archives of virology · 2026Article
- Article
- Diving into the hidden viral world of marine protists.Journal of virology · 2026Review
- Metaviromic insights into the viral community associated with Dendrobium catenatum.Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology] · 2026Article
- A comprehensive comparative genomic analysis of the endogenous Florendovirus-1 inFrontiers in plant science · 2026Article
- Comparative genomics of an Antarctic sea-ice diatom (Frontiers in microbiology · 2026Article
- Engineering TCR-directed T-cells for the treatment of multiple myeloma.Frontiers in immunology · 2026Review
- Development of evolutionarily conserved viral integration sites as safe harbors for human gene therapy.iScience · 2025Article
- Comprehensive characterization of non-retroviral endogenous viral elements in the rice pest Chilo suppressalis.BMC genomics · 2025Article
- Retroviral insertions contributed to the divergence of human and chimpanzee brains.bioRxiv : the preprint server for biology · 2025Article
325 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
Abstract
Recent studies have uncovered myriad viral sequences that are integrated or 'endogenized' in the genomes of various eukaryotes. Surprisingly, it appears that not just retroviruses but almost all types of viruses can become endogenous. We review how these genomic 'fossils' offer fresh insights into the origin, evolutionary dynamics and structural evolution of viruses, which are giving rise to the burgeoning field of palaeovirology. We also examine the multitude of ways through which endogenous viruses have influenced, for better or worse, the biology of their hosts. We argue that the conflict between hosts and viruses has led to the invention and diversification of molecular arsenals, which, in turn, promote the cellular co-option of endogenous viruses.
Indexed as
Identifiers
22421730What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.