ReviewAmerican journal of physiology. Gastrointestinal and liver physiology2012
Review: Experimental models for Barrett's esophagus and esophageal adenocarcinoma.
Review in American journal of physiology. Gastrointestinal and liver physiology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
16 citing papers in PubMed, 33 citations in OpenAlex.
- Safety and performance of the HYBRIDknife flex in a porcine model of esophageal endoscopic submucosal dissection: A pilot study.JGH open : an open access journal of gastroenterology and hepatology · 2024Article
- Chemopreventive Properties of Black Raspberries and Strawberries in Esophageal Cancer Review.Antioxidants (Basel, Switzerland) · 2022Review
- Immunologic and pathologic characterization of a novel swine biomedical research model for eosinophilic esophagitis.Frontiers in allergy · 2022Article
- Barrett's Epithelium to Esophageal Adenocarcinoma: Is There a "Point of No Return"?Frontiers in genetics · 2021Article
- Current concepts in tumour-derived organoids.British journal of cancer · 2020Review
- Organoid cultures recapitulate esophageal adenocarcinoma heterogeneity providing a model for clonality studies and precision therapeutics.Nature communications · 2018Article
- Porcine Esophageal Submucosal Gland Culture Model Shows Capacity for Proliferation and Differentiation.Cellular and molecular gastroenterology and hepatology · 2017Article
- Ductular and proliferative response of esophageal submucosal glands in a porcine model of esophageal injury and repair.American journal of physiology. Gastrointestinal and liver physiology · 2017Article
- Large Animal Models: The Key to Translational Discovery in Digestive Disease Research.Cellular and molecular gastroenterology and hepatology · 2016Article
- Authentication and characterisation of a new oesophageal adenocarcinoma cell line: MFD-1.Scientific reports · 2016Article
- Ductal metaplasia in oesophageal submucosal glands is associated with inflammation and oesophageal adenocarcinoma.Histopathology · 2015Article
- Animal Models of Barrett's Esophagus and Esophageal Adenocarcinoma-Past, Present, and Future.Clinical and translational science · 2015Review
- Surgical Models of Gastroesophageal Reflux with Mice.Journal of visualized experiments : JoVE · 2015Article
- The Barrett's Gland in Phenotype Space.Cellular and molecular gastroenterology and hepatology · 2015Review
- Detection of fluorescent organic nanoparticles by confocal laser endomicroscopy in a rat model of Barrett's esophageal adenocarcinoma.International journal of nanomedicine · 2015Article
- Modeling inflammation and oxidative stress in gastrointestinal disease development using novel organotypic culture systems.Stem cell research & therapy · 2013Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 3 institutions in 1 country.
Funding
Abstract
Several different cell culture systems and laboratory animal models have been used over the years to study Barrett's esophagus (BE) and esophageal adenocarcinoma (EAC). Most of the existing models have key differences with the human esophagus and complex pathogenesis of disease. None of the models offers an ideal system for the complex study of environmental exposure, genetic risk, and prevention strategies. In fact, different model systems may be required to answer different specific research questions about the pathogenesis of BE and EAC. Given the high mortality associated with EAC and the fact that current screening strategies miss most cases of EAC, advances in basic and translational science related to esophageal injury, repair, and carcinogenesis are clearly needed. This review describes several of the existing and potential model systems for BE and EAC with their benefits and disadvantages.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.