Evidence map›Paper›PMID 22421062›Full record

ReviewTrends in cell biology2012

Nucleosome positioning: bringing order to the eukaryotic genome.

Vishwanath R Iyer

Open access · greenAbstract readReview
In one paragraph

Review in Trends in cell biology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.

0numbers the graph read from it
0cells of the map it votes in
35citing papers in PubMed
4.2field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

35 citing papers in PubMed, 58 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Circadian regulation of stereotypic chromatin conformations at enhancers.bioRxiv : the preprint server for biology · 2024
    Article
  5. Article
  6. Review
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Pathway swapping: Toward modular engineering of essential cellular processes.Proceedings of the National Academy of Sciences of the United States of America · 2016
    Article
  16. Article
  17. Review
  18. Review
  19. Article
  20. High-density nucleosome occupancy map of human chromosome 9p21-22 reveals chromatin organization of the type I interferon gene cluster.Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research · 2014
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

1 author at 1 institution in 1 country.

Vishwanath R IyerInstitute for Cellular and Molecular Biology, Center for Systems and Synthetic Biology, and Section of Molecular Genetics and Microbiology, University of Texas at Austin, 1 University Station A4800, Austin, TX 78712-0159, USA. vishy.iyer@gmail.com
The University of Texas at Austin · US

Funding

Comprehensive Identification of Active Functional Elements in Human ChromatinU54HG004563 · NHGRI · DUKE UNIVERSITY · PI CRAWFORD, GREGORY E · 2007 to 2011
$9.7M
Analysis of genome wide transcriptional control in yeastR01CA095548 · NCI · UNIVERSITY OF TEXAS AUSTIN · PI IYER, VISHWANATH R · 2004 to 2013
$2.6M
Gene regulatory networks during the transition from quiescence to proliferationR01CA130075 · NCI · UNIVERSITY OF TEXAS AT AUSTIN · PI IYER, VISHWANATH R · 2008 to 2012
$1.2M
NCI NIH HHS CA095548NCI NIH HHS CA130075NCI NIH HHS R01 CA095548NCI NIH HHS R01 CA130075NHGRI NIH HHS HG004563NHGRI NIH HHS U54 HG004563
6 · The paper itself

Abstract

Nucleosomes are an essential component of eukaryotic chromosomes. The impact of nucleosomes is seen not just on processes that directly access the genome, such as transcription, but also on an evolutionary timescale. Recent studies in various organisms have provided high-resolution maps of nucleosomes throughout the genome. Computational analysis, in conjunction with many other kinds of data, has shed light on several aspects of nucleosome biology. Nucleosomes are positioned by several means, including intrinsic sequence biases, by stacking against a fixed barrier, by DNA-binding proteins and by chromatin remodelers. These studies underscore the important organizational role of nucleosomes in all eukaryotic genomes. This paper reviews recent genomic studies that have shed light on the determinants of nucleosome positioning and their impact on the genome.

Indexed as

GenomeNucleosomesAnimalsChromatinEukaryotic CellsHumansSequence Analysis, DNAChromatinNucleosomes

Identifiers

PMID22421062
PMCPMC3348441
OpenAlexW1969614302

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.