ArticleDevelopmental cell2012
Barriers to male transmission of mitochondrial DNA in sperm development.
Article in Developmental cell, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 88 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
88 citing papers in PubMed, 190 citations in OpenAlex.
- Paternal leakage of mitochondrial DNA is genetically controlled in Drosophila.G3 (Bethesda, Md.) · 2026Article
- Mitochondrial DNA Inheritance and Germline Purifying Selection: Insights FromAnnual review of genetics · 2026Review
- Human Endonuclease G Preferentially Cleaves Oxidatively Damaged DNA.Biochemistry · 2026Article
- ALKB-1-dependent tRNA methylation is required for efficient paternal mitochondrial elimination.Nature communications · 2026Article
- Phosphomimetic Experiments Do Not Support a Causal Role for TFAM Phosphorylation in mtDNA Elimination in Sperm.Journal of molecular biology · 2025Article
- Mitochondrial curation for the next generation.Current opinion in genetics & development · 2025Review
- Asymmetric partitioning of persistent paternal mitochondria during cell divisions safeguards embryo development and mitochondrial inheritance.Developmental cell · 2025Article
- Sperm mtDNA Copy Number Is Not Associated With Midpiece Size Among Songbirds.Ecology and evolution · 2025Article
- Article
- Moderate embryonic delay of paternal mitochondrial elimination impairs mating and cognition and alters behaviors of adult animals.Science advances · 2024Article
- Endonuclease G is dispensable for sperm mitochondrial DNA elimination during spermatogenesis in mice.Biology open · 2024Article
- Egg multivesicular bodies elicit an LC3-associated phagocytosis-like pathway to degrade paternal mitochondria after fertilization.Nature communications · 2024Article
- Maternal mitochondrial function affects paternal mitochondrial inheritance in Drosophila.Genetics · 2024Article
- Mitochondrial Differentiation during Spermatogenesis: Lessons fromInternational journal of molecular sciences · 2024Review
- Sperm function, mitochondrial activity and in vivo fertility are associated to their mitochondrial DNA content in pigs.Journal of animal science and biotechnology · 2024Article
- Structure and molecular basis of spermatid elongation in theOpen biology · 2023Review
- Molecular basis for maternal inheritance of human mitochondrial DNA.Nature genetics · 2023Article
- Effects of adverse fertility-related factors on mitochondrial DNA in the oocyte: a comprehensive review.Reproductive biology and endocrinology : RB&E · 2023Review
- An antibody free approach to probe the presence of poly-ubiquitin chains onmicroPublication biology · 2023Article
- Article
28 more citing papers are in PubMed but not listed here.
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Across the eukaryotic phylogeny, offspring usually inherit their mitochondrial genome from only one of two parents: in animals, the female. Although mechanisms that eliminate paternally derived mitochondria from the zygote have been sought, the developmental stage at which paternal transmission of mitochondrial DNA is restricted is unknown in most animals. Here, we show that the mitochondria of mature Drosophila sperm lack DNA, and we uncover two processes that eliminate mitochondrial DNA during spermatogenesis. Visualization of mitochondrial DNA nucleoids revealed their abrupt disappearance from developing spermatids in a process requiring the mitochondrial nuclease, Endonuclease G. In Endonuclease G mutants, persisting nucleoids are swept out of spermatids by a cellular remodeling process that trims and shapes spermatid tails. Our results show that mitochondrial DNA is eliminated during spermatogenesis, thereby removing the capacity of sperm to transmit the mitochondrial genome to the next generation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.