Evidence map›Paper›PMID 22421036›Full record

ArticleDevelopmental cell2012

Eliminating mitochondrial DNA from sperm.

David C Chan, Eric A Schon

Abstract readComment
In one paragraph

Article in Developmental cell, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed.

  1. Review
  2. Review
  3. Review
  4. Article
  5. Article
  6. Article
  7. Review
  8. Research progress in mitochondrial gene editing technology.Zhejiang da xue xue bao. Yi xue ban = Journal of Zhejiang University. Medical sciences · 2023
    Article
  9. Article
  10. Article
  11. Review
  12. Article
  13. Article
  14. Article
  15. Review
  16. Article
  17. Article
  18. Article
  19. DNA abandonment and the mechanisms of uniparental inheritance of mitochondria and chloroplasts.Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology · 2013
    Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

2 authors.

David C ChanDivision of Biology, California Institute of Technology, and the Howard Hughes Medical Institute, Pasadena, CA 91125, USA. dchan@caltech.edu
Eric A Schon

Funding

Mitochondrial Fusion: Analysis of Fzo FunctionR01GM062967 · NIGMS · CALIFORNIA INSTITUTE OF TECHNOLOGY · PI CHAN, DAVID C · 2001 to 2014
$3.7M
Structural and mechanistic studies of mitochondrial fissionR01GM083121 · NIGMS · CALIFORNIA INSTITUTE OF TECHNOLOGY · PI CHAN, DAVID C · 2007 to 2010
$1.4M
Howard Hughes Medical InstituteNIGMS NIH HHS R01 GM062967NIGMS NIH HHS R01 GM083121
6 · The paper itself

Abstract

Most eukaryotes show uniparental inheritance of mitochondrial DNA (mtDNA). In this issue of Developmental Cell, DeLuca and O'Farrell (2012) show that active elimination of mtDNA during sperm development in Drosophila ensures that mature spermatozoa are devoid of DNA.

Identifiers

PMID22421036
PMCPMC3995028

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.